Greasy GLUT1 maintains glioblastoma malignancy

How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports gly...

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Detalles Bibliográficos
Autores principales: Liu, Caiyun, Li, Xinjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997295/
https://www.ncbi.nlm.nih.gov/pubmed/35419476
http://dx.doi.org/10.1080/23723556.2021.2009423
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author Liu, Caiyun
Li, Xinjian
author_facet Liu, Caiyun
Li, Xinjian
author_sort Liu, Caiyun
collection PubMed
description How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports glycolysis, proliferation, colony formation, and tumorigenicity of glioblastoma cells.
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spelling pubmed-89972952022-04-12 Greasy GLUT1 maintains glioblastoma malignancy Liu, Caiyun Li, Xinjian Mol Cell Oncol Commentary How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports glycolysis, proliferation, colony formation, and tumorigenicity of glioblastoma cells. Taylor & Francis 2021-12-08 /pmc/articles/PMC8997295/ /pubmed/35419476 http://dx.doi.org/10.1080/23723556.2021.2009423 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Liu, Caiyun
Li, Xinjian
Greasy GLUT1 maintains glioblastoma malignancy
title Greasy GLUT1 maintains glioblastoma malignancy
title_full Greasy GLUT1 maintains glioblastoma malignancy
title_fullStr Greasy GLUT1 maintains glioblastoma malignancy
title_full_unstemmed Greasy GLUT1 maintains glioblastoma malignancy
title_short Greasy GLUT1 maintains glioblastoma malignancy
title_sort greasy glut1 maintains glioblastoma malignancy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997295/
https://www.ncbi.nlm.nih.gov/pubmed/35419476
http://dx.doi.org/10.1080/23723556.2021.2009423
work_keys_str_mv AT liucaiyun greasyglut1maintainsglioblastomamalignancy
AT lixinjian greasyglut1maintainsglioblastomamalignancy

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