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Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells

TP53 mutation is one of the most frequent gene mutations in head and neck squamous cell carcinoma (HNSCC) and could be a potential therapeutic target. Recently, the WEE1 G2 checkpoint kinase (WEE1) inhibitor adavosertib (Adv) has attracted attention because of its selective cytotoxicity against TP53...

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Detalles Bibliográficos
Autores principales:	Miyake, Keitaro, Takano, Naoharu, Kazama, Hiromi, Kikuchi, Hiroyuki, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997343/ https://www.ncbi.nlm.nih.gov/pubmed/35348191 http://dx.doi.org/10.3892/ijo.2022.5344

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