Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of CHEK2, BRCA2, and RB1

SIMPLE SUMMARY: Aberrations of DNA damage repair (DDR) pathways enable the transformation of pre-neoplastic lesions, but their roles are barely understood in gastrointestinal stromal tumors (GISTs). The targeted next-generation sequencing of GISTs has demonstrated heterozygous deletions (HetDels) as...

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Detalles Bibliográficos
Autores principales: Liu, Ting-Ting, Li, Chien-Feng, Tan, Kien-Thiam, Jan, Yi-Hua, Lee, Pei-Hang, Huang, Chih-Hao, Yu, Shih-Chen, Tsao, Cheng-Feng, Wang, Jui-Chu, Huang, Hsuan-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997382/
https://www.ncbi.nlm.nih.gov/pubmed/35406559
http://dx.doi.org/10.3390/cancers14071787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997382/
https://www.ncbi.nlm.nih.gov/pubmed/35406559
http://dx.doi.org/10.3390/cancers14071787

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