5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells

5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a...

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Detalles Bibliográficos
Autores principales: Filip, Kamila, Lewińska, Anna, Adamczyk-Grochala, Jagoda, Marino Gammazza, Antonella, Cappello, Francesco, Lauricella, Marianna, Wnuk, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997412/
https://www.ncbi.nlm.nih.gov/pubmed/35406777
http://dx.doi.org/10.3390/cells11071213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997412/
https://www.ncbi.nlm.nih.gov/pubmed/35406777
http://dx.doi.org/10.3390/cells11071213

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