Cargando…
5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells
5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a...
Autores principales: | Filip, Kamila, Lewińska, Anna, Adamczyk-Grochala, Jagoda, Marino Gammazza, Antonella, Cappello, Francesco, Lauricella, Marianna, Wnuk, Maciej |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997412/ https://www.ncbi.nlm.nih.gov/pubmed/35406777 http://dx.doi.org/10.3390/cells11071213 |
Ejemplares similares
-
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence
por: Bloniarz, Dominika, et al.
Publicado: (2021) -
Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells
por: Zabek, Tomasz, et al.
Publicado: (2023) -
DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis
por: Adamczyk-Grochala, Jagoda, et al.
Publicado: (2022) -
Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
por: Lewinska, Anna, et al.
Publicado: (2017) -
Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells
por: Adamczyk-Grochala, Jagoda, et al.
Publicado: (2020)