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Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

Traumatic brain injury (TBI) is a significant global health problem, for which no disease-modifying therapeutics are currently available to improve survival and outcomes. Current neuromonitoring modalities are unable to reflect the complex and changing pathophysiological processes of the acute chang...

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Autores principales: Stevens, Andrew R., Stickland, Clarissa A., Harris, Georgia, Ahmed, Zubair, Goldberg Oppenheimer, Pola, Belli, Antonio, Davies, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997459/
https://www.ncbi.nlm.nih.gov/pubmed/35406790
http://dx.doi.org/10.3390/cells11071227
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author Stevens, Andrew R.
Stickland, Clarissa A.
Harris, Georgia
Ahmed, Zubair
Goldberg Oppenheimer, Pola
Belli, Antonio
Davies, David J.
author_facet Stevens, Andrew R.
Stickland, Clarissa A.
Harris, Georgia
Ahmed, Zubair
Goldberg Oppenheimer, Pola
Belli, Antonio
Davies, David J.
author_sort Stevens, Andrew R.
collection PubMed
description Traumatic brain injury (TBI) is a significant global health problem, for which no disease-modifying therapeutics are currently available to improve survival and outcomes. Current neuromonitoring modalities are unable to reflect the complex and changing pathophysiological processes of the acute changes that occur after TBI. Raman spectroscopy (RS) is a powerful, label-free, optical tool which can provide detailed biochemical data in vivo. A systematic review of the literature is presented of available evidence for the use of RS in TBI. Seven research studies met the inclusion/exclusion criteria with all studies being performed in pre-clinical models. None of the studies reported the in vivo application of RS, with spectral acquisition performed ex vivo and one performed in vitro. Four further studies were included that related to the use of RS in analogous brain injury models, and a further five utilised RS in ex vivo biofluid studies for diagnosis or monitoring of TBI. RS is identified as a potential means to identify injury severity and metabolic dysfunction which may hold translational value. In relation to the available evidence, the translational potentials and barriers are discussed. This systematic review supports the further translational development of RS in TBI to fully ascertain its potential for enhancing patient care.
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spelling pubmed-89974592022-04-12 Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives Stevens, Andrew R. Stickland, Clarissa A. Harris, Georgia Ahmed, Zubair Goldberg Oppenheimer, Pola Belli, Antonio Davies, David J. Cells Systematic Review Traumatic brain injury (TBI) is a significant global health problem, for which no disease-modifying therapeutics are currently available to improve survival and outcomes. Current neuromonitoring modalities are unable to reflect the complex and changing pathophysiological processes of the acute changes that occur after TBI. Raman spectroscopy (RS) is a powerful, label-free, optical tool which can provide detailed biochemical data in vivo. A systematic review of the literature is presented of available evidence for the use of RS in TBI. Seven research studies met the inclusion/exclusion criteria with all studies being performed in pre-clinical models. None of the studies reported the in vivo application of RS, with spectral acquisition performed ex vivo and one performed in vitro. Four further studies were included that related to the use of RS in analogous brain injury models, and a further five utilised RS in ex vivo biofluid studies for diagnosis or monitoring of TBI. RS is identified as a potential means to identify injury severity and metabolic dysfunction which may hold translational value. In relation to the available evidence, the translational potentials and barriers are discussed. This systematic review supports the further translational development of RS in TBI to fully ascertain its potential for enhancing patient care. MDPI 2022-04-05 /pmc/articles/PMC8997459/ /pubmed/35406790 http://dx.doi.org/10.3390/cells11071227 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Stevens, Andrew R.
Stickland, Clarissa A.
Harris, Georgia
Ahmed, Zubair
Goldberg Oppenheimer, Pola
Belli, Antonio
Davies, David J.
Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title_full Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title_fullStr Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title_full_unstemmed Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title_short Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives
title_sort raman spectroscopy as a neuromonitoring tool in traumatic brain injury: a systematic review and clinical perspectives
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997459/
https://www.ncbi.nlm.nih.gov/pubmed/35406790
http://dx.doi.org/10.3390/cells11071227
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