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Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice

PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS), a type of anaemia, due to abnormal red blood cell function. Here, we hypothesised additional effects on the heart. Consistent...

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Detalles Bibliográficos
Autores principales:	Bartoli, Fiona, Evans, Elizabeth L., Blythe, Nicola M., Stewart, Leander, Chuntharpursat-Bon, Eulashini, Debant, Marjolaine, Musialowski, Katie E., Lichtenstein, Laeticia, Parsonage, Gregory, Futers, T. Simon, Turner, Neil A., Beech, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997529/ https://www.ncbi.nlm.nih.gov/pubmed/35406763 http://dx.doi.org/10.3390/cells11071199

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