Cargando…

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

SIMPLE SUMMARY: RNA binding proteins (RBPs) post-transcriptionally regulate and stabilize a variety of target mRNA transcripts. Human Antigen R (HuR) binds to several pro-survival mRNA transcripts and promotes tumor cell survival and chemotherapeutic resistance. Some of these targets are within the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jain, Aditi, McCoy, Matthew, Coats, Carolyn, Brown, Samantha Z., Addya, Sankar, Pelz, Carl, Sears, Rosalie C., Yeo, Charles J., Brody, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997573/ https://www.ncbi.nlm.nih.gov/pubmed/35406624 http://dx.doi.org/10.3390/cancers14071848

Ejemplares similares

Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity
por: McCarthy, Grace A, et al.
Publicado: (2023)

BRCA1-BARD1: the importance of being in shape
por: Daza-Martin, Manuel, et al.
Publicado: (2019)

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
por: Yi, Jie, et al.
Publicado: (2010)

Differential Expression of BARD1 Isoforms in Melanoma
por: McDougall, Lorissa I., et al.
Publicado: (2021)

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1
por: Witus, Samuel R., et al.
Publicado: (2021)

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
por: Zhu, Qian, et al.
Publicado: (2021)

Regulation of cyclin D(1 )by the BRCA1–BARD1 complex
por: Murray, MM, et al.
Publicado: (2008)

Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans
por: Thapa, Ishor, et al.
Publicado: (2022)

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats
por: Ferrigno, Andrea, et al.
Publicado: (2023)

Regulation of AT1R expression through HuR by insulin
por: Paukku, Kirsi, et al.
Publicado: (2012)

Expression of BARD1 β Isoform in Selected Pediatric Tumors
por: Jasiak, Anna, et al.
Publicado: (2021)

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2019)

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
por: Minten, Elizabeth V., et al.
Publicado: (2021)

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
por: Yoon, Je-Hyun, et al.
Publicado: (2014)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2023)

The Function of BARD1 in Centrosome Regulation in Cooperation with BRCA1/OLA1/RACK1
por: Otsuka, Kei, et al.
Publicado: (2020)

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ
por: Bunch, Heeyoun, et al.
Publicado: (2021)

Loss of CARM1 is linked to reduced HuR function in replicative senescence
por: Pang, Lijun, et al.
Publicado: (2013)

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR
por: Phillips, Brittany L, et al.
Publicado: (2018)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract
por: Barrows, John K, et al.
Publicado: (2021)

The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
por: Wu, Duo, et al.
Publicado: (2023)

BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
por: Burdett, Hayden, et al.
Publicado: (2023)

CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability
por: Liu, Fei, et al.
Publicado: (2022)

53bp1 mutation enhances brca1 and bard1 embryonic lethality in C. elegans
por: Hariri, Sara, et al.
Publicado: (2023)

Circular RNA circStag1 promotes bone regeneration by interacting with HuR
por: Chen, Gaoyang, et al.
Publicado: (2022)

Germline mutations of BRCA1-associated RING domain (BARD1) gene in breast and/or ovarian families negative for BRCA1 and 2 alterations
por: Ghimenti, C, et al.
Publicado: (2000)

Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis
por: García-Domínguez, Daniel J., et al.
Publicado: (2011)

Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models
por: Authiat, Marcella M., et al.
Publicado: (2022)

BRCA1–BARD1 Regulates Axon Regeneration in Concert with the Gqα–DAG Signaling Network
por: Sakai, Yoshiki, et al.
Publicado: (2021)

Regulation of HuR by DNA Damage Response Kinases
por: Kim, Hyeon Ho, et al.
Publicado: (2010)

Regulation of HuR structure and function by dihydrotanshinone-I
por: Lal, Preet, et al.
Publicado: (2017)

Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
por: Lachiondo-Ortega, Sofia, et al.
Publicado: (2022)

AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders
por: Trojanowicz, Bogusz, et al.
Publicado: (2011)

The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response
por: Diaz-Muñoz, Manuel D., et al.
Publicado: (2015)

LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
por: Kim, Jiyoung, et al.
Publicado: (2016)

HuR‐regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer
por: Chai, Yiqing, et al.
Publicado: (2016)

HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
por: Noh, Ji Heon, et al.
Publicado: (2016)

Triciribine Engages ZFP36L1 and HuR to Stabilize LDLR mRNA
por: Sundvold, Hilde
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lsv4hlk72l89ovaeoj9ku80tvq