Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities in astrocytes from mice with SOD1 mutations (mSOD1-ALS) can now be explored in human patients using somatic ce...

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Detalles Bibliográficos
Autores principales: Gomes, Cátia, Sequeira, Catarina, Likhite, Shibi, Dennys, Cassandra N., Kolb, Stephen J., Shaw, Pamela J., Vaz, Ana R., Kaspar, Brian K., Meyer, Kathrin, Brites, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997588/
https://www.ncbi.nlm.nih.gov/pubmed/35406750
http://dx.doi.org/10.3390/cells11071186

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