Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer

SIMPLE SUMMARY: High throughput exome sequencing approaches have disclosed recurrent cancer-associated mutations in spliceosomal components, which drive aberrant pre-mRNA processing events and support the tumor phenotype. At the same time, mutations in spliceosome genes and aberrant splicing regulat...

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Detalles Bibliográficos
Autores principales: Sette, Claudio, Paronetto, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997811/
https://www.ncbi.nlm.nih.gov/pubmed/35406598
http://dx.doi.org/10.3390/cancers14071827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997811/
https://www.ncbi.nlm.nih.gov/pubmed/35406598
http://dx.doi.org/10.3390/cancers14071827

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