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The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation

The objective of this paper is to analyze the association of intraluminal thrombus (ILT) presence and morphology with oxygen transport in abdominal aortic aneurysms (AAA) and local hypoxia. The biomechanical role of the ILT layer in the evolution of the aneurysm is still not fully understood. ILT ha...

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Autores principales: Carbino, Burton, Guy, Alexander, Durka, Michael, Zakerzadeh, Rana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997837/
https://www.ncbi.nlm.nih.gov/pubmed/35419349
http://dx.doi.org/10.3389/fbioe.2022.814995
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author Carbino, Burton
Guy, Alexander
Durka, Michael
Zakerzadeh, Rana
author_facet Carbino, Burton
Guy, Alexander
Durka, Michael
Zakerzadeh, Rana
author_sort Carbino, Burton
collection PubMed
description The objective of this paper is to analyze the association of intraluminal thrombus (ILT) presence and morphology with oxygen transport in abdominal aortic aneurysms (AAA) and local hypoxia. The biomechanical role of the ILT layer in the evolution of the aneurysm is still not fully understood. ILT has been shown to create an inflammatory environment by reducing oxygen flux to the arterial wall and therefore decreasing its strength. It has been also hypothesized that the geometry of the ILT may further affect AAA rupture. However, no previous research has attempted to explore the effect of morphological features of ILT on oxygen distributions within the AAA, in a systematic manner. In this study, we perform a comprehensive analysis to investigate how physiologically meaningful variations in ILT geometric characteristics affect oxygen transport within an AAA. We simulate twenty-seven AAA models with variable ILT dimensions and investigate the extent to which ILT attenuates oxygen concentration in the arterial wall. Geometric variations studied include ILT thickness and ILT length, as well as the bulge diameter of the aneurysm which is related to ILT curvature. Computer simulations of coupled fluid flow-mass transport between arterial wall, ILT, and blood are solved and spatial variations of oxygen concentrations within the ILT and wall are obtained. The comparison of the results for all twenty-seven simulations supports the hypothesis that the presence of ILT in AAA correlates to significantly impaired oxygen transport to the aneurysmal wall. Mainly, we observed that ILT thickness and length are the parameters that influence decreased oxygen flow and concentration values the most, and thick thrombi exacerbate hypoxic conditions in the arterial wall, which may contribute to increased tissue degradation. Conversely, we observed that the arterial wall oxygen concentration is nearly independent of the AAA bulge diameter. This confirms that consideration of ILT size and anatomy is crucial in the analysis of AAA development.
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spelling pubmed-89978372022-04-12 The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation Carbino, Burton Guy, Alexander Durka, Michael Zakerzadeh, Rana Front Bioeng Biotechnol Bioengineering and Biotechnology The objective of this paper is to analyze the association of intraluminal thrombus (ILT) presence and morphology with oxygen transport in abdominal aortic aneurysms (AAA) and local hypoxia. The biomechanical role of the ILT layer in the evolution of the aneurysm is still not fully understood. ILT has been shown to create an inflammatory environment by reducing oxygen flux to the arterial wall and therefore decreasing its strength. It has been also hypothesized that the geometry of the ILT may further affect AAA rupture. However, no previous research has attempted to explore the effect of morphological features of ILT on oxygen distributions within the AAA, in a systematic manner. In this study, we perform a comprehensive analysis to investigate how physiologically meaningful variations in ILT geometric characteristics affect oxygen transport within an AAA. We simulate twenty-seven AAA models with variable ILT dimensions and investigate the extent to which ILT attenuates oxygen concentration in the arterial wall. Geometric variations studied include ILT thickness and ILT length, as well as the bulge diameter of the aneurysm which is related to ILT curvature. Computer simulations of coupled fluid flow-mass transport between arterial wall, ILT, and blood are solved and spatial variations of oxygen concentrations within the ILT and wall are obtained. The comparison of the results for all twenty-seven simulations supports the hypothesis that the presence of ILT in AAA correlates to significantly impaired oxygen transport to the aneurysmal wall. Mainly, we observed that ILT thickness and length are the parameters that influence decreased oxygen flow and concentration values the most, and thick thrombi exacerbate hypoxic conditions in the arterial wall, which may contribute to increased tissue degradation. Conversely, we observed that the arterial wall oxygen concentration is nearly independent of the AAA bulge diameter. This confirms that consideration of ILT size and anatomy is crucial in the analysis of AAA development. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8997837/ /pubmed/35419349 http://dx.doi.org/10.3389/fbioe.2022.814995 Text en Copyright © 2022 Carbino, Guy, Durka and Zakerzadeh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Carbino, Burton
Guy, Alexander
Durka, Michael
Zakerzadeh, Rana
The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title_full The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title_fullStr The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title_full_unstemmed The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title_short The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation
title_sort effects of geometric features of intraluminal thrombus on the vessel wall oxygen deprivation
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997837/
https://www.ncbi.nlm.nih.gov/pubmed/35419349
http://dx.doi.org/10.3389/fbioe.2022.814995
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