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The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders

The effects of COVID-19 on the human body are not yet understood enough. Medical history provides information on cases of psychiatric symptoms during viral infections in the 20th century, such as the influenza pandemic. Currently, it is observed that there is an increasing number of new psychiatric...

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Autores principales: Łoś, Kacper, Kulikowska, Joanna, Waszkiewicz, Napoleon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997854/
https://www.ncbi.nlm.nih.gov/pubmed/35409462
http://dx.doi.org/10.3390/ijerph19073781
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author Łoś, Kacper
Kulikowska, Joanna
Waszkiewicz, Napoleon
author_facet Łoś, Kacper
Kulikowska, Joanna
Waszkiewicz, Napoleon
author_sort Łoś, Kacper
collection PubMed
description The effects of COVID-19 on the human body are not yet understood enough. Medical history provides information on cases of psychiatric symptoms during viral infections in the 20th century, such as the influenza pandemic. Currently, it is observed that there is an increasing number of new psychiatric disorders in previously healthy individuals. In addition, because of the decreased amount of reporting to health care providers, including psychiatrists, many physicians suggest that the number of neuropsychiatric disorders may be underestimated. In this paper, we review available studies on the occurrence of first-time psychotic spectrum disorder (PSD) in individuals related to SARS-CoV-2 infection. The reviewed studies suggest that first-time psychotic disorder in COVID-19 patients is statistically significantly more frequent compared to influenza, as well as to other respiratory infections. The emergence of new PSDs is explained by direct neurotropism of the virus on the one hand and by immunological mechanisms on the other. The main conclusions of this review should be treated with caution, and future research on this topic is needed. The authors recognize the particular need to develop standardized laboratory panels that include inflammatory markers (IL-6, TNF-α), cerebrospinal fluid (CSF) testing, and SARS-CoV-2 antibody assays to entirely understand the etiology of neuropsychiatric complications of SARS-CoV-2 infections and the pandemic itself. In addition, public health efforts are required to promote mental health, especially during COVID-19.
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spelling pubmed-89978542022-04-12 The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders Łoś, Kacper Kulikowska, Joanna Waszkiewicz, Napoleon Int J Environ Res Public Health Review The effects of COVID-19 on the human body are not yet understood enough. Medical history provides information on cases of psychiatric symptoms during viral infections in the 20th century, such as the influenza pandemic. Currently, it is observed that there is an increasing number of new psychiatric disorders in previously healthy individuals. In addition, because of the decreased amount of reporting to health care providers, including psychiatrists, many physicians suggest that the number of neuropsychiatric disorders may be underestimated. In this paper, we review available studies on the occurrence of first-time psychotic spectrum disorder (PSD) in individuals related to SARS-CoV-2 infection. The reviewed studies suggest that first-time psychotic disorder in COVID-19 patients is statistically significantly more frequent compared to influenza, as well as to other respiratory infections. The emergence of new PSDs is explained by direct neurotropism of the virus on the one hand and by immunological mechanisms on the other. The main conclusions of this review should be treated with caution, and future research on this topic is needed. The authors recognize the particular need to develop standardized laboratory panels that include inflammatory markers (IL-6, TNF-α), cerebrospinal fluid (CSF) testing, and SARS-CoV-2 antibody assays to entirely understand the etiology of neuropsychiatric complications of SARS-CoV-2 infections and the pandemic itself. In addition, public health efforts are required to promote mental health, especially during COVID-19. MDPI 2022-03-22 /pmc/articles/PMC8997854/ /pubmed/35409462 http://dx.doi.org/10.3390/ijerph19073781 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Łoś, Kacper
Kulikowska, Joanna
Waszkiewicz, Napoleon
The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title_full The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title_fullStr The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title_full_unstemmed The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title_short The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders
title_sort impact of the covid-19 virus pandemic on the incidence of first psychotic spectrum disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997854/
https://www.ncbi.nlm.nih.gov/pubmed/35409462
http://dx.doi.org/10.3390/ijerph19073781
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