Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient therapies. Although protein aggregation is known to be...

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Detalles Bibliográficos
Autores principales: Günther, René, Pal, Arun, Williams, Chloe, Zimyanin, Vitaly L., Liehr, Maria, von Neubeck, Cläre, Krause, Mechthild, Parab, Mrudula G., Petri, Susanne, Kalmbach, Norman, Marklund, Stefan L., Sterneckert, Jared, Munch Andersen, Peter, Wegner, Florian, Gilthorpe, Jonathan D., Hermann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997900/
https://www.ncbi.nlm.nih.gov/pubmed/35406813
http://dx.doi.org/10.3390/cells11071246

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