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A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone

Plasminogen activator inhibitor type-2 (PAI-2), a member of the serpin family, is dramatically upregulated during pregnancy and in response to inflammation. Although PAI-2 exists in glycosylated and non-glycosylated forms in vivo, the majority of in vitro studies of PAI-2 have exclusively involved t...

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Detalles Bibliográficos
Autores principales: Cater, Jordan H., Mañucat-Tan, Noralyn B., Georgiou, Demi K., Zhao, Guomao, Buhimschi, Irina A., Wyatt, Amy R., Ranson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997907/
https://www.ncbi.nlm.nih.gov/pubmed/35406715
http://dx.doi.org/10.3390/cells11071152