Cargando…

The EGFR Signaling Modulates in Mesenchymal Stem Cells the Expression of miRNAs Involved in the Interaction with Breast Cancer Cells

SIMPLE SUMMARY: The epidermal growth factor receptor (EGFR) plays a central role in the tumor microenvironment, through the activation of paracrine and autocrine circuits that promote cancer development and progression. Our study for the first time provides evidence that the EGFR system induces in m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallo, Marianna, Carotenuto, Marianeve, Frezzetti, Daniela, Camerlingo, Rosa, Roma, Cristin, Bergantino, Francesca, Normanno, Nicola, De Luca, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997927/ https://www.ncbi.nlm.nih.gov/pubmed/35406622 http://dx.doi.org/10.3390/cancers14071851

Ejemplares similares

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells
por: De Luca, Antonella, et al.
Publicado: (2014)

Genomic Profiling of KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents
por: Rachiglio, Anna Maria, et al.
Publicado: (2019)

RANTES and IL-6 cooperate in inducing a more aggressive phenotype in breast cancer cells
por: Gallo, Marianna, et al.
Publicado: (2018)

Next Generation Sequencing-Based Profiling of Cell Free DNA in Patients with Advanced Non-Small Cell Lung Cancer: Advantages and Pitfalls
por: Esposito Abate, Riziero, et al.
Publicado: (2020)

Targeted sequencing analysis of cell-free DNA from metastatic non-small-cell lung cancer patients: clinical and biological implications
por: Pasquale, Raffaella, et al.
Publicado: (2020)

Low Impact of Clonal Hematopoiesis on the Determination of RAS Mutations by Cell-Free DNA Testing in Routine Clinical Diagnostics
por: Roma, Cristin, et al.
Publicado: (2022)

Genomic alterations in cholangiocarcinoma: clinical significance and relevance to therapy
por: Carotenuto, Marianeve, et al.
Publicado: (2022)

Circulating Tumor DNA Testing Opens New Perspectives in Melanoma Management
por: Sacco, Alessandra, et al.
Publicado: (2020)

Optimizing response to gefitinib in the treatment of non-small-cell lung cancer
por: Carotenuto, Pietro, et al.
Publicado: (2011)

Challenges in bioinformatics approaches to tumor mutation burden analysis
por: Fenizia, Francesca, et al.
Publicado: (2021)

SARS-CoV-2 complete genome sequencing from the Italian Campania region using a highly automated next generation sequencing system
por: Rachiglio, Anna Maria, et al.
Publicado: (2021)

Promising Role of Circulating Tumor Cells in the Management of SCLC
por: De Luca, Antonella, et al.
Publicado: (2021)

Detection of EGFR Mutations by TaqMan Mutation Detection Assays Powered by Competitive Allele-Specific TaqMan PCR Technology
por: Roma, Cristin, et al.
Publicado: (2013)

The Presence of Concomitant Mutations Affects the Activity of EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC) Patients
por: Rachiglio, Anna Maria, et al.
Publicado: (2019)

cfDNA testing for monitoring response to EGFR tyrosine kinase inhibitors: Time for clinical implementation?
por: Normanno, Nicola, et al.
Publicado: (2020)

Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line
por: Pirozzi, Giuseppe, et al.
Publicado: (2011)

Conditioned medium of primary lung cancer cells induces EMT in A549 lung cancer cell line by TGF-ß1 and miRNA21 cooperation
por: Camerlingo, Rosa, et al.
Publicado: (2019)

miRNAs and resistance to EGFR—TKIs in EGFR-mutant non-small cell lung cancer: beyond ‘traditional mechanisms’ of resistance
por: Ricciuti, Biagio, et al.
Publicado: (2015)

Liquid Biopsy Testing for the Management of Patient with Non-Small Cell Lung Cancer Carrying a Rare Exon-20 EGFR Insertion
por: Morabito, Alessandro, et al.
Publicado: (2022)

miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment
por: Conti, Ilaria, et al.
Publicado: (2020)

MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation
por: De Luca, Luciana, et al.
Publicado: (2015)

Computational identification of miRNAs that modulate the differentiation of mesenchymal stem cells to osteoblasts
por: Seenprachawong, Kanokwan, et al.
Publicado: (2016)

Roles for miRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells
por: Wang, Jicheng, et al.
Publicado: (2019)

The importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation
por: Shirazi, Sajjad, et al.
Publicado: (2021)

Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis
por: Gong, Min, et al.
Publicado: (2017)

Bioinformatics: From NGS Data to Biological Complexity in Variant Detection and Oncological Clinical Practice
por: Dotolo, Serena, et al.
Publicado: (2022)

Guide to detecting epidermal growth factor receptor (EGFR) mutations in ctDNA of patients with advanced non-small-cell lung cancer
por: Normanno, Nicola, et al.
Publicado: (2016)

Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
por: Ragni, Enrico, et al.
Publicado: (2020)

Mesenchymal stem cell-derived exosomes as new tools for delivery of miRNAs in the treatment of cancer
por: Dalmizrak, Aysegul, et al.
Publicado: (2022)

Screening for genes, miRNAs and transcription factors of adipogenic differentiation and dedifferentiation of mesenchymal stem cells
por: Ou-yang, Yi, et al.
Publicado: (2023)

miRNAs halt cell cycle
por: Tuma, Rabiya S.
Publicado: (2006)

The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
por: Bimonte, Sabrina, et al.
Publicado: (2016)

Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles
por: Fafián-Labora, J., et al.
Publicado: (2017)

Regulation of miRNAs by Snail during epithelial-to-mesenchymal transition in HT29 colon cancer cells
por: Przygodzka, Patrycja, et al.
Publicado: (2019)

Hypoxia-Regulated miRNAs in Human Mesenchymal Stem Cells: Exploring the Regulatory Effects in Ischemic Disorders
por: Dell’Aversana, Carmela, et al.
Publicado: (2019)

Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation
por: Giunti, Debora, et al.
Publicado: (2021)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Regulate the Mitochondrial Metabolism via Transfer of miRNAs
por: Loussouarn, Claire, et al.
Publicado: (2021)

Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders
por: Nakano, Masako, et al.
Publicado: (2021)

microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review
por: Makowska, Marianna, et al.
Publicado: (2023)

Ssa miRNAs DB: Online repository of in silico predicted miRNAs in Salmo salar
por: Reyes, Daniela, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1el88pjc0pqhnlln8pnih7ta3l