Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal slice preparations in the stratum lacunosum molecul...

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Detalles Bibliográficos
Autores principales: Spedding, Michael, Sebban, Claude, Jay, Thérèse M., Rocher, Cyril, Tesolin-Decros, Brigitte, Chazot, Paul, Schenker, Esther, Szénási, Gabor, Lévay, György I., Megyeri, Katalin, Barkóczy, Jozsef, Hársing, Laszlo G., Thomson, Ian, Cunningham, Mark O., Whittington, Miles A., Etherington, Lori-An, Lambert, Jeremy J., Antoni, Ferenc A., Gacsályi, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997950/
https://www.ncbi.nlm.nih.gov/pubmed/35406745
http://dx.doi.org/10.3390/cells11071181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997950/
https://www.ncbi.nlm.nih.gov/pubmed/35406745
http://dx.doi.org/10.3390/cells11071181

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