An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives

Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechani...

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Autores principales: Schirone, Leonardo, Forte, Maurizio, D’Ambrosio, Luca, Valenti, Valentina, Vecchio, Daniele, Schiavon, Sonia, Spinosa, Giulia, Sarto, Gianmarco, Petrozza, Vincenzo, Frati, Giacomo, Sciarretta, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998015/
https://www.ncbi.nlm.nih.gov/pubmed/35406729
http://dx.doi.org/10.3390/cells11071165
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author Schirone, Leonardo
Forte, Maurizio
D’Ambrosio, Luca
Valenti, Valentina
Vecchio, Daniele
Schiavon, Sonia
Spinosa, Giulia
Sarto, Gianmarco
Petrozza, Vincenzo
Frati, Giacomo
Sciarretta, Sebastiano
author_facet Schirone, Leonardo
Forte, Maurizio
D’Ambrosio, Luca
Valenti, Valentina
Vecchio, Daniele
Schiavon, Sonia
Spinosa, Giulia
Sarto, Gianmarco
Petrozza, Vincenzo
Frati, Giacomo
Sciarretta, Sebastiano
author_sort Schirone, Leonardo
collection PubMed
description Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.
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spelling pubmed-89980152022-04-12 An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives Schirone, Leonardo Forte, Maurizio D’Ambrosio, Luca Valenti, Valentina Vecchio, Daniele Schiavon, Sonia Spinosa, Giulia Sarto, Gianmarco Petrozza, Vincenzo Frati, Giacomo Sciarretta, Sebastiano Cells Review Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling. MDPI 2022-03-30 /pmc/articles/PMC8998015/ /pubmed/35406729 http://dx.doi.org/10.3390/cells11071165 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schirone, Leonardo
Forte, Maurizio
D’Ambrosio, Luca
Valenti, Valentina
Vecchio, Daniele
Schiavon, Sonia
Spinosa, Giulia
Sarto, Gianmarco
Petrozza, Vincenzo
Frati, Giacomo
Sciarretta, Sebastiano
An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title_full An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title_fullStr An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title_full_unstemmed An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title_short An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
title_sort overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998015/
https://www.ncbi.nlm.nih.gov/pubmed/35406729
http://dx.doi.org/10.3390/cells11071165
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