Cargando…

Protective Effects of Mitochondrial Uncoupling Protein 2 against Aristolochic Acid I-Induced Toxicity in HK-2 Cells

Aristolochic acid I (AA I) is one of the most abundant and toxic aristolochic acids that is reported to cause Aristolochic acid nephropathy (AAN). This paper was designed to assess whether mitochondrial Uncoupling Protein 2 (UCP2), which plays an antioxidative and antiapoptotic role, could protect h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Chen, Anger, Etienne Empweb, Zhang, Xiong, Su, Shengdi, Su, Chenlin, Zhao, Shuxin, Yu, Feng, Li, Ji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998172/ https://www.ncbi.nlm.nih.gov/pubmed/35409033 http://dx.doi.org/10.3390/ijms23073674

Ejemplares similares

Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches
por: Anger, Etienne Empweb, et al.
Publicado: (2020)

Medicinally Used Asarum Species: High-Resolution LC-MS Analysis of Aristolochic Acid Analogs and In vitro Toxicity Screening in HK-2 Cells
por: Michl, Johanna, et al.
Publicado: (2017)

Preparation of Anti-Aristolochic Acid I Monoclonal Antibody and Development of Chemiluminescent Immunoassay and Carbon Dot-Based Fluoroimmunoassay for Sensitive Detection of Aristolochic Acid I
por: Ou, Ai-Fen, et al.
Publicado: (2021)

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP(+) Toxicity in Neuronal Cells
por: Ho, Philip Wing-Lok, et al.
Publicado: (2009)

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes
por: Roberts, David J., et al.
Publicado: (2013)

Overview of aristolochic acid nephropathy: an update
por: Zhou, Qingqing, et al.
Publicado: (2023)

The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro
por: Wang, Liping, et al.
Publicado: (2019)

Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats
por: Bárta, František, et al.
Publicado: (2021)

Combination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway
por: Zhang, Xiong, et al.
Publicado: (2022)

Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy
por: Yi, Joo-Hark, et al.
Publicado: (2018)

Aristolochic acid I exposure decreases oocyte quality
por: Li, Weidong, et al.
Publicado: (2022)

Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury
por: Sun, Jian, et al.
Publicado: (2023)

Acute and Subchronic Toxicity Studies of Aristolochic Acid A in Tianfu Broilers
por: Xu, Dan, et al.
Publicado: (2021)

Comparative Analysis of Aristolochic Acids in Aristolochia Medicinal Herbs and Evaluation of Their Toxicities
por: Zhang, Shu-Han, et al.
Publicado: (2022)

Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
por: Juretzko, Annett, et al.
Publicado: (2022)

The mitochondrial uncoupling proteins
por: Ledesma, Amalia, et al.
Publicado: (2002)

Empagliflozin Protects HK-2 Cells from High Glucose-Mediated Injuries via a Mitochondrial Mechanism
por: Lee, Wen-Chin, et al.
Publicado: (2019)

Molecular Dynamics Simulations of Mitochondrial Uncoupling Protein 2
por: Škulj, Sanja, et al.
Publicado: (2021)

Aristolochic Acid I-Induced Hepatotoxicity in Tianfu Broilers Is Associated with Oxidative-Stress-Mediated Apoptosis and Mitochondrial Damage
por: Xu, Dan, et al.
Publicado: (2021)

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission‐VDAC1‐HK2‐mPTP‐mitophagy axis
por: Zhou, Hao, et al.
Publicado: (2017)

Mitochondrial uncouplers inhibit hepatic stellate cell activation
por: Guimarães, Eduardo L, et al.
Publicado: (2012)

Regulation on Calcium Oxalate Crystallization and Protection on HK-2 Cells of Tea Polysaccharides with Different Molecular Weights
por: Liu, Hong, et al.
Publicado: (2020)

Smad7 protects against chronic aristolochic acid nephropathy in mice
por: Dai, Xiao-Yu, et al.
Publicado: (2015)

Protective Effects of Melatonin Against Aristolochic Acid-Induced Nephropathy in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2019)

Aristolochic Acid Causes Albuminuria by Promoting Mitochondrial DNA Damage and Dysfunction in Podocyte
por: Zhou, Yang, et al.
Publicado: (2013)

Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells
por: Kudryavtseva, Anna V., et al.
Publicado: (2016)

Isolation, Characterization and Quantity Determination of Aristolochic Acids, Toxic Compounds in Aristolochia bracteolata L.
por: Abdelgadir, Abdelgadir A., et al.
Publicado: (2011)

Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen
por: Jabůrek, Martin, et al.
Publicado: (2018)

Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation
por: Kakarla, Mamatha, et al.
Publicado: (2019)

Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor
por: Wang, Ke, et al.
Publicado: (2015)

Genipin Inhibits Mitochondrial Uncoupling Protein 2 Expression and Ameliorates Podocyte Injury in Diabetic Mice
por: Qiu, Wenjing, et al.
Publicado: (2012)

The Ginsenoside Rg(1) Rescues Mitochondrial Disorders in Aristolochic Acid-Induced Nephropathic Mice
por: Chou, Chu-Kuang, et al.
Publicado: (2021)

Update of aristolochic acid nephropathy in Korea
por: Ban, Tae Hyun, et al.
Publicado: (2018)

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo
por: Sborchia, Mateja, et al.
Publicado: (2019)

Protective Role of Mitochondrial Uncoupling Proteins against Age-Related Oxidative Stress in Type 2 Diabetes Mellitus
por: Čater, Maša, et al.
Publicado: (2022)

Mitochondrial uncoupling proteins and energy metabolism
por: Busiello, Rosa A., et al.
Publicado: (2015)

Circadian regulation of mitochondrial uncoupling and lifespan
por: Ulgherait, Matt, et al.
Publicado: (2020)

Circadian Regulation of Mitochondrial Uncoupling and Lifespan
por: Ulgherait, Matthew
Publicado: (2020)

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes
por: Hinder, Lucy M., et al.
Publicado: (2019)

Uncoupling mitochondrial uncoupling from alternative substrate utilization: implications for heavy intensity exercise
por: Goulding, Richie P., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t4d18kse3buck8m5pkutljgsej