Role and Regulation of Pif1 Family Helicases at the Replication Fork

Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication thr...

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Detalles Bibliográficos
Autores principales: Malone, Emory G., Thompson, Matthew D., Byrd, Alicia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998199/
https://www.ncbi.nlm.nih.gov/pubmed/35409096
http://dx.doi.org/10.3390/ijms23073736
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author Malone, Emory G.
Thompson, Matthew D.
Byrd, Alicia K.
author_facet Malone, Emory G.
Thompson, Matthew D.
Byrd, Alicia K.
author_sort Malone, Emory G.
collection PubMed
description Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication through many barriers such as G-quadruplex DNA, the rDNA replication fork barrier, tRNA genes, and R-loops. Pif1 helicases also regulate telomerase and promote replication termination, Okazaki fragment maturation, and break-induced replication. This review highlights many of the roles and regulations of Pif1 at the replication fork that promote cellular health and viability.
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spelling pubmed-89981992022-04-12 Role and Regulation of Pif1 Family Helicases at the Replication Fork Malone, Emory G. Thompson, Matthew D. Byrd, Alicia K. Int J Mol Sci Review Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication through many barriers such as G-quadruplex DNA, the rDNA replication fork barrier, tRNA genes, and R-loops. Pif1 helicases also regulate telomerase and promote replication termination, Okazaki fragment maturation, and break-induced replication. This review highlights many of the roles and regulations of Pif1 at the replication fork that promote cellular health and viability. MDPI 2022-03-29 /pmc/articles/PMC8998199/ /pubmed/35409096 http://dx.doi.org/10.3390/ijms23073736 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malone, Emory G.
Thompson, Matthew D.
Byrd, Alicia K.
Role and Regulation of Pif1 Family Helicases at the Replication Fork
title Role and Regulation of Pif1 Family Helicases at the Replication Fork
title_full Role and Regulation of Pif1 Family Helicases at the Replication Fork
title_fullStr Role and Regulation of Pif1 Family Helicases at the Replication Fork
title_full_unstemmed Role and Regulation of Pif1 Family Helicases at the Replication Fork
title_short Role and Regulation of Pif1 Family Helicases at the Replication Fork
title_sort role and regulation of pif1 family helicases at the replication fork
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998199/
https://www.ncbi.nlm.nih.gov/pubmed/35409096
http://dx.doi.org/10.3390/ijms23073736
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