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Tumor Necrosis Factor-α Induces a Preeclamptic-like Phenotype in Placental Villi via Sphingosine Kinase 1 Activation

Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of TNF-α signaling is unclear...

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Detalles Bibliográficos
Autores principales:	Fakhr, Yuliya, Koshti, Saloni, Habibyan, Yasaman Bahojb, Webster, Kirsten, Hemmings, Denise G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998215/ https://www.ncbi.nlm.nih.gov/pubmed/35409108 http://dx.doi.org/10.3390/ijms23073750

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