PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells

Cancer cells are known to have chromosomal number abnormalities (aneuploidy), a hallmark of malignant tumors. Cancer cells also have an increased number of centrosomes (centrosome amplification). Paradoxically, cancer therapies, including γ-irradiation and some anticancer drugs, are carcinogenic and...

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Detalles Bibliográficos
Autores principales: Tanaka, Masakazu, Mushiake, Masatoshi, Takahashi, Jun, Sasaki, Yuka, Yamashita, Sachiko, Ida, Chieri, Masutani, Mitsuko, Miwa, Masanao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998298/
https://www.ncbi.nlm.nih.gov/pubmed/35408845
http://dx.doi.org/10.3390/ijms23073484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998298/
https://www.ncbi.nlm.nih.gov/pubmed/35408845
http://dx.doi.org/10.3390/ijms23073484

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