Cargando…

PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells

Cancer cells are known to have chromosomal number abnormalities (aneuploidy), a hallmark of malignant tumors. Cancer cells also have an increased number of centrosomes (centrosome amplification). Paradoxically, cancer therapies, including γ-irradiation and some anticancer drugs, are carcinogenic and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Masakazu, Mushiake, Masatoshi, Takahashi, Jun, Sasaki, Yuka, Yamashita, Sachiko, Ida, Chieri, Masutani, Mitsuko, Miwa, Masanao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998298/ https://www.ncbi.nlm.nih.gov/pubmed/35408845 http://dx.doi.org/10.3390/ijms23073484

Ejemplares similares

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
por: Iovino, Flora, et al.
Publicado: (2006)

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
por: Zamora, Ruben, et al.
Publicado: (2010)

ADP-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control
por: Poltronieri, Palmiro, et al.
Publicado: (2021)

Physiological levels of poly(ADP-ribose) during the cell cycle regulate HeLa cell proliferation
por: Yamashita, Sachiko, et al.
Publicado: (2022)

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4(+) T cells
por: Park, Jung-Eun, et al.
Publicado: (2023)

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
por: Roper, Stephen J., et al.
Publicado: (2014)

Cortical dynein drives centrosome clustering in cells with centrosome amplification
por: Mercadante, Dayna L., et al.
Publicado: (2023)

Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes
por: Kasbek, Christopher, et al.
Publicado: (2010)

Impairment in S-phase entry of splenocytes of Parp-1 knockout mice
por: Watanabe, Fumiaki, et al.
Publicado: (2004)

Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice
por: Fujihara, Hisako, et al.
Publicado: (2019)

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
por: Dementyeva, Elena, et al.
Publicado: (2013)

Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells
por: Ogino, Hideki, et al.
Publicado: (2004)

Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors
por: Wang, Junhui, et al.
Publicado: (2015)

HTLV-1 Tax: centrosome amplification and cancer
por: Pumfery, Anne, et al.
Publicado: (2006)

Targeting centrosome amplification, an Achilles' heel of cancer
por: Sabat-Pośpiech, Dorota, et al.
Publicado: (2019)

The G(1 )phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
por: Harrison, Mary K, et al.
Publicado: (2011)

Inhibition of Poly (ADP-Ribose) Glycohydrolase Accelerates Osteoblast Differentiation in Preosteoblastic MC3T3-E1 Cells
por: Sasaki, Yuka, et al.
Publicado: (2022)

PARP6 inhibition as a strategy to exploit centrosome clustering in cancer cells?
por: Wang, Zebin, et al.
Publicado: (2019)

A Clinical Overview of Centrosome Amplification in Human Cancers
por: Chan, Jason Yongsheng
Publicado: (2011)

Loss of KLF14 triggers centrosome amplification and tumorigenesis
por: Fan, Guangjian, et al.
Publicado: (2015)

Centrosome amplification disrupts renal development and causes cystogenesis
por: Dionne, Lai Kuan, et al.
Publicado: (2018)

Oncosuppressive functions of PIDD1 in response to centrosome amplification
por: Vitale, Ilio, et al.
Publicado: (2021)

Analysis of the “centrosome-ome” identifies MCPH1 deletion as a cause of centrosome amplification in human cancer
por: Denu, Ryan A., et al.
Publicado: (2020)

XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA
por: Hirota, Kouji, et al.
Publicado: (2022)

Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death
por: Ogden, A, et al.
Publicado: (2014)

BRCA1 transports the DNA damage signal for CDDP‐induced centrosome amplification through the centrosomal Aurora A
por: Qi, Huicheng, et al.
Publicado: (2022)

Multiplying madly: Deacetylases take charge of centrosome duplication and amplification
por: Hung, Hui-Fang, et al.
Publicado: (2012)

Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors
por: Mercey, Olivier, et al.
Publicado: (2019)

Patterns of selection against centrosome amplification in human cell lines
por: Dias Louro, Marco António, et al.
Publicado: (2021)

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
por: Sauer, Carolin M., et al.
Publicado: (2023)

The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation
por: Conduit, Paul T., et al.
Publicado: (2014)

Erratum to “Impairment in S-phase entry of splenocytes of Parp-1 knockout mice”: [Proc. Jpn. Acad., Ser. B 79, No. 8, 248–251 (2003)]
por: Watanabe, Fumiaki, et al.
Publicado: (2004)

Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo
por: Yasukawa, Masaaki, et al.
Publicado: (2016)

Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction
por: Au, Franco K.C., et al.
Publicado: (2020)

Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer
por: Zhang, Yu, et al.
Publicado: (2013)

14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression
por: Mukhopadhyay, Amitabha, et al.
Publicado: (2016)

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
por: Shumilov, Anatoliy, et al.
Publicado: (2017)

Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
por: LEONTOVICH, ALEXEY A., et al.
Publicado: (2013)

The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
por: Shahi, Aashirwad, et al.
Publicado: (2022)

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
por: Zhang, Chenggang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fch691k49npkeuv8b1hekl8fh1