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Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits
Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-rel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998417/ https://www.ncbi.nlm.nih.gov/pubmed/35408943 http://dx.doi.org/10.3390/ijms23073582 |
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author | Park, Hee Ra Cai, Mudan Yang, Eun Jin |
author_facet | Park, Hee Ra Cai, Mudan Yang, Eun Jin |
author_sort | Park, Hee Ra |
collection | PubMed |
description | Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-related disorders. Dysregulation of specific brain regions and neural circuits, particularly the hippocampus, amygdala, and medial prefrontal cortex, have been demonstrated in patients with these disorders. These regions are involved in learning, memory, consolidation, and extinction. These are also the brain regions where new neurons are generated and are crucial for memory formation and integration. Therefore, these three brain regions and neural circuits have contributed greatly to studies on neural plasticity and structural remodeling in patients with psychiatric disorders. In this review, we provide an understanding of fear memory and its underlying cellular mechanisms and describe how neural circuits are involved in fear memory. Additionally, we discuss therapeutic interventions for these disorders based on their proneurogenic efficacy and the neural circuits involved in fear memory. |
format | Online Article Text |
id | pubmed-8998417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89984172022-04-12 Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits Park, Hee Ra Cai, Mudan Yang, Eun Jin Int J Mol Sci Review Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-related disorders. Dysregulation of specific brain regions and neural circuits, particularly the hippocampus, amygdala, and medial prefrontal cortex, have been demonstrated in patients with these disorders. These regions are involved in learning, memory, consolidation, and extinction. These are also the brain regions where new neurons are generated and are crucial for memory formation and integration. Therefore, these three brain regions and neural circuits have contributed greatly to studies on neural plasticity and structural remodeling in patients with psychiatric disorders. In this review, we provide an understanding of fear memory and its underlying cellular mechanisms and describe how neural circuits are involved in fear memory. Additionally, we discuss therapeutic interventions for these disorders based on their proneurogenic efficacy and the neural circuits involved in fear memory. MDPI 2022-03-25 /pmc/articles/PMC8998417/ /pubmed/35408943 http://dx.doi.org/10.3390/ijms23073582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Hee Ra Cai, Mudan Yang, Eun Jin Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title | Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title_full | Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title_fullStr | Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title_full_unstemmed | Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title_short | Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits |
title_sort | neurogenic interventions for fear memory via modulation of the hippocampal function and neural circuits |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998417/ https://www.ncbi.nlm.nih.gov/pubmed/35408943 http://dx.doi.org/10.3390/ijms23073582 |
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