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Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established tar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998427/ https://www.ncbi.nlm.nih.gov/pubmed/35409143 http://dx.doi.org/10.3390/ijms23073784 |
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author | Vertecchi, Eleonora Rizzo, Angela Salvati, Erica |
author_facet | Vertecchi, Eleonora Rizzo, Angela Salvati, Erica |
author_sort | Vertecchi, Eleonora |
collection | PubMed |
description | Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different “telosome” components. |
format | Online Article Text |
id | pubmed-8998427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89984272022-04-12 Telomere Targeting Approaches in Cancer: Beyond Length Maintenance Vertecchi, Eleonora Rizzo, Angela Salvati, Erica Int J Mol Sci Review Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different “telosome” components. MDPI 2022-03-29 /pmc/articles/PMC8998427/ /pubmed/35409143 http://dx.doi.org/10.3390/ijms23073784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vertecchi, Eleonora Rizzo, Angela Salvati, Erica Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title | Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title_full | Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title_fullStr | Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title_full_unstemmed | Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title_short | Telomere Targeting Approaches in Cancer: Beyond Length Maintenance |
title_sort | telomere targeting approaches in cancer: beyond length maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998427/ https://www.ncbi.nlm.nih.gov/pubmed/35409143 http://dx.doi.org/10.3390/ijms23073784 |
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