Telomere Targeting Approaches in Cancer: Beyond Length Maintenance

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established tar...

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Detalles Bibliográficos
Autores principales: Vertecchi, Eleonora, Rizzo, Angela, Salvati, Erica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998427/
https://www.ncbi.nlm.nih.gov/pubmed/35409143
http://dx.doi.org/10.3390/ijms23073784
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author Vertecchi, Eleonora
Rizzo, Angela
Salvati, Erica
author_facet Vertecchi, Eleonora
Rizzo, Angela
Salvati, Erica
author_sort Vertecchi, Eleonora
collection PubMed
description Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different “telosome” components.
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spelling pubmed-89984272022-04-12 Telomere Targeting Approaches in Cancer: Beyond Length Maintenance Vertecchi, Eleonora Rizzo, Angela Salvati, Erica Int J Mol Sci Review Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different “telosome” components. MDPI 2022-03-29 /pmc/articles/PMC8998427/ /pubmed/35409143 http://dx.doi.org/10.3390/ijms23073784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vertecchi, Eleonora
Rizzo, Angela
Salvati, Erica
Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title_full Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title_fullStr Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title_full_unstemmed Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title_short Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
title_sort telomere targeting approaches in cancer: beyond length maintenance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998427/
https://www.ncbi.nlm.nih.gov/pubmed/35409143
http://dx.doi.org/10.3390/ijms23073784
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AT salvatierica telomeretargetingapproachesincancerbeyondlengthmaintenance

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