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Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
The activity of the epithelial Na(+) Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (βN1 and γN2). The affinities of these sites were previously d...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998630/ https://www.ncbi.nlm.nih.gov/pubmed/35409240 http://dx.doi.org/10.3390/ijms23073884 |