EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AML

Nucleophosmin-1 (NPM1) is a pleiotropic protein involved in numerous cellular processes. NPM1 shuttles between the nucleus and the cytoplasm, but exhibits a predominant nucleolar localization, where its fate and functions are exquisitely controlled by dynamic post-translational modifications (PTM)....

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Detalles Bibliográficos
Autores principales: Skayneh, Hala, Jishi, Batoul, Hleihel, Rita, Hamie, Maguy, El Hajj, Rana, Deleuze-Masquefa, Carine, Bonnet, Pierre-Antoine, El Sabban, Marwan, El Hajj, Hiba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998649/
https://www.ncbi.nlm.nih.gov/pubmed/35408798
http://dx.doi.org/10.3390/ijms23073421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998649/
https://www.ncbi.nlm.nih.gov/pubmed/35408798
http://dx.doi.org/10.3390/ijms23073421

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