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Fragment-Based Discovery of AF9 YEATS Domain Inhibitors
YEATS (YAF9, ENL, AF9, TAF14, SAS5) family proteins recognize acylated histones and in turn regulate chromatin structure, gene transcription, and stress signaling. The chromosomal translocations of ENL and mixed lineage leukemia are considered oncogenic drivers in acute myeloid leukemia and acute ly...
Autores principales: | Liu, Yaqian, Jin, Ruoxing, Lu, Hui, Bian, Kangjie, Wang, Rui, Wang, Lei, Gao, Rui, Zhang, Jiahai, Wu, Jihui, Yao, Xuebiao, Liu, Xing, Liu, Dan, Wang, Xisheng, Zhang, Zhiyong, Ruan, Ke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998803/ https://www.ncbi.nlm.nih.gov/pubmed/35409252 http://dx.doi.org/10.3390/ijms23073893 |
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