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Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

YEATS (YAF9, ENL, AF9, TAF14, SAS5) family proteins recognize acylated histones and in turn regulate chromatin structure, gene transcription, and stress signaling. The chromosomal translocations of ENL and mixed lineage leukemia are considered oncogenic drivers in acute myeloid leukemia and acute ly...

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Detalles Bibliográficos
Autores principales:	Liu, Yaqian, Jin, Ruoxing, Lu, Hui, Bian, Kangjie, Wang, Rui, Wang, Lei, Gao, Rui, Zhang, Jiahai, Wu, Jihui, Yao, Xuebiao, Liu, Xing, Liu, Dan, Wang, Xisheng, Zhang, Zhiyong, Ruan, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998803/ https://www.ncbi.nlm.nih.gov/pubmed/35409252 http://dx.doi.org/10.3390/ijms23073893

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