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Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study

Objectives: To investigate whether chronic obstructive pulmonary disease (COPD) affects nonapnea sleep disorder (NASD) on the risk of obesity. Materials and Methods: From 1 January 2000 to 31 December 2015, a total of 24,363 patients with obesity from the 2005 Longitudinal Health Insurance Database...

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Autores principales: Yu, Pi-Ching, Chung, Ren-Jei, Huang, Yao-Ching, Huang, Shi-Hao, Wang, Bing-Long, Chien, Wu-Chien, Chung, Chi-Hsiang, Sun, Chien-An, Yang, Sung-Sen, Wu, Gwo-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998813/
https://www.ncbi.nlm.nih.gov/pubmed/35409801
http://dx.doi.org/10.3390/ijerph19074118
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author Yu, Pi-Ching
Chung, Ren-Jei
Huang, Yao-Ching
Huang, Shi-Hao
Wang, Bing-Long
Chien, Wu-Chien
Chung, Chi-Hsiang
Sun, Chien-An
Yang, Sung-Sen
Wu, Gwo-Jang
author_facet Yu, Pi-Ching
Chung, Ren-Jei
Huang, Yao-Ching
Huang, Shi-Hao
Wang, Bing-Long
Chien, Wu-Chien
Chung, Chi-Hsiang
Sun, Chien-An
Yang, Sung-Sen
Wu, Gwo-Jang
author_sort Yu, Pi-Ching
collection PubMed
description Objectives: To investigate whether chronic obstructive pulmonary disease (COPD) affects nonapnea sleep disorder (NASD) on the risk of obesity. Materials and Methods: From 1 January 2000 to 31 December 2015, a total of 24,363 patients with obesity from the 2005 Longitudinal Health Insurance Database were identified; 97,452 patients without obesity were also identified from the same database. Multiple logistic regression was used to analyze the previous exposure risk of patients with obesity and NASD. A p value of <0.05 was considered significant. Results: The risk of developing obesity in patients with COPD is 3.05 times higher than that in patients without COPD. Patients with COPD with NASD had a 1.606-fold higher risk of developing obesity than those without NASD. Patients with obesity were more likely to be exposed to NASD than did those without obesity (adjusted odds ratio, 1.693; 95% confidence interval, 1.575–1.821, p < 0.001). Furthermore, the closeness of the exposure period to the index time was positively associated with the severity of obesity, with a dose–response effect. The exposure duration of NASD in patients with obesity was 1.693 times than that in those without obesity. Longer exposure durations were associated with more severe obesity, also with a dose–response effect. Conclusions: The COPD effect of NASD increases the subsequent risk of obesity, and the risk of obesity was determined to be significantly higher in patients with NASD in this case–control study. Longer exposure to NASD was associated with a higher likelihood of obesity, also with a dose–response effect.
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spelling pubmed-89988132022-04-12 Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study Yu, Pi-Ching Chung, Ren-Jei Huang, Yao-Ching Huang, Shi-Hao Wang, Bing-Long Chien, Wu-Chien Chung, Chi-Hsiang Sun, Chien-An Yang, Sung-Sen Wu, Gwo-Jang Int J Environ Res Public Health Article Objectives: To investigate whether chronic obstructive pulmonary disease (COPD) affects nonapnea sleep disorder (NASD) on the risk of obesity. Materials and Methods: From 1 January 2000 to 31 December 2015, a total of 24,363 patients with obesity from the 2005 Longitudinal Health Insurance Database were identified; 97,452 patients without obesity were also identified from the same database. Multiple logistic regression was used to analyze the previous exposure risk of patients with obesity and NASD. A p value of <0.05 was considered significant. Results: The risk of developing obesity in patients with COPD is 3.05 times higher than that in patients without COPD. Patients with COPD with NASD had a 1.606-fold higher risk of developing obesity than those without NASD. Patients with obesity were more likely to be exposed to NASD than did those without obesity (adjusted odds ratio, 1.693; 95% confidence interval, 1.575–1.821, p < 0.001). Furthermore, the closeness of the exposure period to the index time was positively associated with the severity of obesity, with a dose–response effect. The exposure duration of NASD in patients with obesity was 1.693 times than that in those without obesity. Longer exposure durations were associated with more severe obesity, also with a dose–response effect. Conclusions: The COPD effect of NASD increases the subsequent risk of obesity, and the risk of obesity was determined to be significantly higher in patients with NASD in this case–control study. Longer exposure to NASD was associated with a higher likelihood of obesity, also with a dose–response effect. MDPI 2022-03-30 /pmc/articles/PMC8998813/ /pubmed/35409801 http://dx.doi.org/10.3390/ijerph19074118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Pi-Ching
Chung, Ren-Jei
Huang, Yao-Ching
Huang, Shi-Hao
Wang, Bing-Long
Chien, Wu-Chien
Chung, Chi-Hsiang
Sun, Chien-An
Yang, Sung-Sen
Wu, Gwo-Jang
Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title_full Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title_fullStr Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title_full_unstemmed Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title_short Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
title_sort chronic obstructive pulmonary disease effect of nonapnea sleep disorder on the risk of obesity: a nationwide population-based case–control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998813/
https://www.ncbi.nlm.nih.gov/pubmed/35409801
http://dx.doi.org/10.3390/ijerph19074118
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