Metastasis and MAPK Pathways

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growt...

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Autores principales: Kciuk, Mateusz, Gielecińska, Adrianna, Budzinska, Adrianna, Mojzych, Mariusz, Kontek, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998814/
https://www.ncbi.nlm.nih.gov/pubmed/35409206
http://dx.doi.org/10.3390/ijms23073847
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author Kciuk, Mateusz
Gielecińska, Adrianna
Budzinska, Adrianna
Mojzych, Mariusz
Kontek, Renata
author_facet Kciuk, Mateusz
Gielecińska, Adrianna
Budzinska, Adrianna
Mojzych, Mariusz
Kontek, Renata
author_sort Kciuk, Mateusz
collection PubMed
description Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process.
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spelling pubmed-89988142022-04-12 Metastasis and MAPK Pathways Kciuk, Mateusz Gielecińska, Adrianna Budzinska, Adrianna Mojzych, Mariusz Kontek, Renata Int J Mol Sci Review Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process. MDPI 2022-03-31 /pmc/articles/PMC8998814/ /pubmed/35409206 http://dx.doi.org/10.3390/ijms23073847 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kciuk, Mateusz
Gielecińska, Adrianna
Budzinska, Adrianna
Mojzych, Mariusz
Kontek, Renata
Metastasis and MAPK Pathways
title Metastasis and MAPK Pathways
title_full Metastasis and MAPK Pathways
title_fullStr Metastasis and MAPK Pathways
title_full_unstemmed Metastasis and MAPK Pathways
title_short Metastasis and MAPK Pathways
title_sort metastasis and mapk pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998814/
https://www.ncbi.nlm.nih.gov/pubmed/35409206
http://dx.doi.org/10.3390/ijms23073847
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AT budzinskaadrianna metastasisandmapkpathways
AT mojzychmariusz metastasisandmapkpathways
AT kontekrenata metastasisandmapkpathways

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