Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway

Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1β/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3. In this work, we investigated whether Natterin activates mitochondrial damage, resulti...

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Detalles Bibliográficos
Autores principales: Lima, Carla, Andrade-Barros, Aline Ingrid, Bernardo, Jefferson Thiago Gonçalves, Balogh, Eniko, Quesniaux, Valerie F., Ryffel, Bernhard, Lopes-Ferreira, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998820/
https://www.ncbi.nlm.nih.gov/pubmed/35408954
http://dx.doi.org/10.3390/ijms23073600

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