Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

Rac1 is a small Rho GTPase that is activated in platelets upon stimulation with various ligands, including collagen and thrombin, which are ligands for the glycoprotein VI (GPVI) receptor and the protease-activated receptors, respectively. Rac1-deficient murine platelets have impaired lamellipodia f...

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Detalles Bibliográficos
Autores principales: Neagoe, Raluca A. I., Gardiner, Elizabeth E., Stegner, David, Nieswandt, Bernhard, Watson, Steve P., Poulter, Natalie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998833/
https://www.ncbi.nlm.nih.gov/pubmed/35409124
http://dx.doi.org/10.3390/ijms23073746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998833/
https://www.ncbi.nlm.nih.gov/pubmed/35409124
http://dx.doi.org/10.3390/ijms23073746

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