Cargando…

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

Rac1 is a small Rho GTPase that is activated in platelets upon stimulation with various ligands, including collagen and thrombin, which are ligands for the glycoprotein VI (GPVI) receptor and the protease-activated receptors, respectively. Rac1-deficient murine platelets have impaired lamellipodia f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neagoe, Raluca A. I., Gardiner, Elizabeth E., Stegner, David, Nieswandt, Bernhard, Watson, Steve P., Poulter, Natalie S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998833/ https://www.ncbi.nlm.nih.gov/pubmed/35409124 http://dx.doi.org/10.3390/ijms23073746

Ejemplares similares

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
por: Poulter, N. S., et al.
Publicado: (2017)

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
por: Jooss, Natalie J., et al.
Publicado: (2022)

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
por: Koo, Chek Ziu, et al.
Publicado: (2022)

Comparison of the GPVI inhibitors losartan and honokiol
por: Onselaer, Marie-Blanche, et al.
Publicado: (2019)

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation
por: Haining, Elizabeth J., et al.
Publicado: (2016)

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function
por: Navarro, Stefano, et al.
Publicado: (2022)

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System
por: Perrella, Gina, et al.
Publicado: (2021)

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation
por: Unsworth, Amanda J., et al.
Publicado: (2019)

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
por: Billiald, Philippe, et al.
Publicado: (2022)

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation
por: Akbar, Huzoor, et al.
Publicado: (2011)

Targeting GPVI as a novel antithrombotic strategy
por: Andrews, Robert K, et al.
Publicado: (2014)

Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation
por: Nestele, Jeremy A., et al.
Publicado: (2021)

Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies
por: Jamasbi, Janina, et al.
Publicado: (2015)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

GPVI expression is linked to platelet size, age, and reactivity
por: Veninga, Alicia, et al.
Publicado: (2022)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice
por: Schuhmann, Michael K., et al.
Publicado: (2019)

Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia
por: Tantawy, Azza Abdel Gawad, et al.
Publicado: (2022)

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
por: Jung, Stephanie M., et al.
Publicado: (2012)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice
por: Eaton, Nathan, et al.
Publicado: (2020)

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
por: Kaiser, Rainer, et al.
Publicado: (2022)

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis
por: Ye, Yujia, et al.
Publicado: (2023)

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets
por: Zhou, Jing, et al.
Publicado: (2020)

A tail of two ITAMs: GPVI/FcRγ and FcγRIIa's role in platelet activation and thrombus stability
por: Neeves, Keith B.
Publicado: (2021)

Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia
por: Hardy, Alexander T., et al.
Publicado: (2018)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation()
por: Walsh, T.G., et al.
Publicado: (2014)

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner
por: Hoermann, Henrike, et al.
Publicado: (2021)

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains
por: Protty, Majd B., et al.
Publicado: (2008)

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing
por: Taylor, Lewis, et al.
Publicado: (2014)

Glaucocalyxin A Inhibits Platelet Activation and Thrombus Formation Preferentially via GPVI Signaling Pathway
por: Li, Wei, et al.
Publicado: (2013)

A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
por: Shih, Tzenge‐Lien, et al.
Publicado: (2021)

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1
por: De Simone, Ilaria, et al.
Publicado: (2022)

GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region
por: Xu, Rui-Gang, et al.
Publicado: (2021)

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling
por: Judd, Barbi A., et al.
Publicado: (2002)

Role of Focal Adhesion Tyrosine Kinases in GPVI-Dependent Platelet Activation and Reactive Oxygen Species Formation
por: Carrim, Naadiya, et al.
Publicado: (2014)

Agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage
por: Hosseini, Ehteramolsadat, et al.
Publicado: (2022)

Should aspirin be replaced with ADP blockers and anti-GPVI to manage thrombosis?
por: Khan, Hafsa, et al.
Publicado: (2022)

MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation
por: Howes, Joanna‐Marie, et al.
Publicado: (2018)

Correction to: agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage
por: Hosseini, Ehteramolsadat, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hj9thuk3sufq8kfsfvgnbkv3tc