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Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases
Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well esta...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/ https://www.ncbi.nlm.nih.gov/pubmed/35408994 http://dx.doi.org/10.3390/ijms23073636 |
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author | Buonacera, Agata Stancanelli, Benedetta Colaci, Michele Malatino, Lorenzo |
author_facet | Buonacera, Agata Stancanelli, Benedetta Colaci, Michele Malatino, Lorenzo |
author_sort | Buonacera, Agata |
collection | PubMed |
description | Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity. |
format | Online Article Text |
id | pubmed-8998851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89988512022-04-12 Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases Buonacera, Agata Stancanelli, Benedetta Colaci, Michele Malatino, Lorenzo Int J Mol Sci Review Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity. MDPI 2022-03-26 /pmc/articles/PMC8998851/ /pubmed/35408994 http://dx.doi.org/10.3390/ijms23073636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Buonacera, Agata Stancanelli, Benedetta Colaci, Michele Malatino, Lorenzo Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title_full | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title_fullStr | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title_full_unstemmed | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title_short | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
title_sort | neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/ https://www.ncbi.nlm.nih.gov/pubmed/35408994 http://dx.doi.org/10.3390/ijms23073636 |
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