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Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses

Apolipoprotein E (ApoE) is a multifunctional protein expressed in several tissues, including those of the liver. This lipoprotein component is responsible for maintaining lipid content homeostasis at the plasma and tissue levels by transporting lipids between the liver and peripheral tissues. The ab...

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Autores principales: Tréguier, Yannick, Bull-Maurer, Anne, Roingeard, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998859/
https://www.ncbi.nlm.nih.gov/pubmed/35409035
http://dx.doi.org/10.3390/ijms23073676
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author Tréguier, Yannick
Bull-Maurer, Anne
Roingeard, Philippe
author_facet Tréguier, Yannick
Bull-Maurer, Anne
Roingeard, Philippe
author_sort Tréguier, Yannick
collection PubMed
description Apolipoprotein E (ApoE) is a multifunctional protein expressed in several tissues, including those of the liver. This lipoprotein component is responsible for maintaining lipid content homeostasis at the plasma and tissue levels by transporting lipids between the liver and peripheral tissues. The ability of ApoE to interact with host-cell surface receptors and its involvement in several cellular pathways raised questions about the hijacking of ApoE by hepatotropic viruses. Hepatitis C virus (HCV) was the first hepatitis virus reported to be dependent on ApoE for the completion of its lifecycle, with ApoE being part of the viral particle, mediating its entry into host cells and contributing to viral morphogenesis. Recent studies of the hepatitis B virus (HBV) lifecycle have revealed that this virus and its subviral envelope particles also incorporate ApoE. ApoE favors HBV entry and is crucial for the morphogenesis of infectious particles, through its interaction with HBV envelope glycoproteins. This review summarizes the data highlighting the crucial role of ApoE in the lifecycles of HBV and HCV and discusses its potential role in the lifecycle of other hepatotropic viruses.
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spelling pubmed-89988592022-04-12 Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses Tréguier, Yannick Bull-Maurer, Anne Roingeard, Philippe Int J Mol Sci Review Apolipoprotein E (ApoE) is a multifunctional protein expressed in several tissues, including those of the liver. This lipoprotein component is responsible for maintaining lipid content homeostasis at the plasma and tissue levels by transporting lipids between the liver and peripheral tissues. The ability of ApoE to interact with host-cell surface receptors and its involvement in several cellular pathways raised questions about the hijacking of ApoE by hepatotropic viruses. Hepatitis C virus (HCV) was the first hepatitis virus reported to be dependent on ApoE for the completion of its lifecycle, with ApoE being part of the viral particle, mediating its entry into host cells and contributing to viral morphogenesis. Recent studies of the hepatitis B virus (HBV) lifecycle have revealed that this virus and its subviral envelope particles also incorporate ApoE. ApoE favors HBV entry and is crucial for the morphogenesis of infectious particles, through its interaction with HBV envelope glycoproteins. This review summarizes the data highlighting the crucial role of ApoE in the lifecycles of HBV and HCV and discusses its potential role in the lifecycle of other hepatotropic viruses. MDPI 2022-03-27 /pmc/articles/PMC8998859/ /pubmed/35409035 http://dx.doi.org/10.3390/ijms23073676 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tréguier, Yannick
Bull-Maurer, Anne
Roingeard, Philippe
Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title_full Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title_fullStr Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title_full_unstemmed Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title_short Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses
title_sort apolipoprotein e, a crucial cellular protein in the lifecycle of hepatitis viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998859/
https://www.ncbi.nlm.nih.gov/pubmed/35409035
http://dx.doi.org/10.3390/ijms23073676
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