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Identification and New Indication of Melanin-Concentrating Hormone Receptor 1 (MCHR1) Antagonist Derived from Machine Learning and Transcriptome-Based Drug Repositioning Approaches

Melanin-concentrating hormone receptor 1 (MCHR1) has been a target for appetite suppressants, which are helpful in treating obesity. However, it is challenging to develop an MCHR1 antagonist because its binding site is similar to that of the human Ether-à-go-go-Related Gene (hERG) channel, whose inh...

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Detalles Bibliográficos
Autores principales:	Lim, Gyutae, You, Ka Young, Lee, Jeong Hyun, Jeon, Moon Kook, Lee, Byung Ho, Ryu, Jae Yong, Oh, Kwang-Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998904/ https://www.ncbi.nlm.nih.gov/pubmed/35409167 http://dx.doi.org/10.3390/ijms23073807

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