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Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities

Melanoma is characterized by high glucose uptake, partially mediated through elevated pyruvate dehydrogenase kinase (PDK), making PDK a potential treatment target in melanoma. We aimed to reduce glucose uptake in melanoma cell lines through PDK inhibitors dichloroacetate (DCA) and AZD7545 and throug...

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Detalles Bibliográficos
Autores principales:	Tiersma, Jiske F., Evers, Bernard, Bakker, Barbara M., Jalving, Mathilde, de Jong, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999016/ https://www.ncbi.nlm.nih.gov/pubmed/35409102 http://dx.doi.org/10.3390/ijms23073745

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