Cargando…

Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP(swe) Alzheimer’s Disease Mouse Model

The free fatty acid FFA3 receptor (FFA3R) belongs to the superfamily of G-protein-coupled receptors (GPCRs). In the intestine and adipose tissue, it is involved in the regulation of energy metabolism, but its function in the brain is unknown. We aimed, first, to investigate the expression of the rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zamarbide, Marta, Martinez-Pinilla, Eva, Gil-Bea, Francisco, Yanagisawa, Masashi, Franco, Rafael, Perez-Mediavilla, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999053/ https://www.ncbi.nlm.nih.gov/pubmed/35408893 http://dx.doi.org/10.3390/ijms23073533

Ejemplares similares

Maternal imprinting on cognition markers of wild type and transgenic Alzheimer’s disease model mice
por: Zamarbide, Marta, et al.
Publicado: (2018)

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
por: Faizi, Mehrdad, et al.
Publicado: (2012)

Phenyl Acyl Acids Attenuate the Unfolded Protein Response in Tunicamycin-Treated Neuroblastoma Cells
por: Zamarbide, Marta, et al.
Publicado: (2013)

Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APP(swe)/PS1(dE9) Mice and Their Wild Type Littermates
por: Zhang, Feng, et al.
Publicado: (2018)

Expression Profiling of Cytokine, Cholinergic Markers, and Amyloid-β Deposition in the APP(SWE)/PS1dE9 Mouse Model of Alzheimer’s Disease Pathology
por: Reale, Marcella, et al.
Publicado: (2018)

Longitudinal investigation of neuroinflammation and metabolite profiles in the APP (swe)×PS1(Δe9) transgenic mouse model of Alzheimer's disease
por: Chaney, Aisling, et al.
Publicado: (2017)

Evodiamine derivatives improve cognitive abilities in APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease
por: Pang, Shuo, et al.
Publicado: (2020)

Cortical iron regulation and inflammatory response in Alzheimer's disease and APP(SWE)/PS1(ΔE9) mice: a histological perspective
por: Meadowcroft, Mark D., et al.
Publicado: (2015)

Reliability of the DSS-Swe Questionnaire
por: Jans, Anders, et al.
Publicado: (2023)

Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APP (Swe) /PS1ΔE9 Transgenic Female Mice
por: Coles, Madilyn, et al.
Publicado: (2020)

The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APP(swe) Cell Model of AD
por: Huang, Xianfeng, et al.
Publicado: (2018)

Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis
por: Briggs, Denise Isabelle, et al.
Publicado: (2017)

Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice
por: O’Neal-Moffitt, G., et al.
Publicado: (2015)

Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APP(swe)/PS1dE9 model of Alzheimer’s disease
por: Ohline, Shane M., et al.
Publicado: (2022)

Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells
por: Zhang, Xueqing, et al.
Publicado: (2019)

Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice
por: de Sousa, Diana M. Bessa, et al.
Publicado: (2023)

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(ΔE9) murine model of Alzheimer’s disease
por: Minter, Myles R., et al.
Publicado: (2017)

Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuro-pathological Hallmarks
por: Domingues, Catarina, et al.
Publicado: (2017)

Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease
por: Price, Brittani R., et al.
Publicado: (2021)

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model
por: Tanghe, An, et al.
Publicado: (2010)

APP(swe) /PS1(ΔE9) mice exhibit low oxygen saturation and alterations of erythrocytes preceding the neuropathology and cognitive deficiency during Alzheimer's disease
por: Wang, Manli, et al.
Publicado: (2023)

Cryo-EM of Aβ fibrils from mouse models find tg-APP(ArcSwe) fibrils resemble those found in patients with sporadic Alzheimer’s disease
por: Zielinski, Mara, et al.
Publicado: (2023)

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice
por: Naert, Gaëlle, et al.
Publicado: (2012)

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells
por: Liang, Jie, et al.
Publicado: (2019)

The Lack of Amyloidogenic Activity Is Persistent in Old WT and APP(swe)/PS1ΔE9 Mouse Retinae
por: Joly, Sandrine, et al.
Publicado: (2021)

Validation of the Swedish Trauma Registry (SweTrau)
por: Holmberg, Lina, et al.
Publicado: (2023)

Generation and Characterization of the First Murine Model of Alzheimer’s Disease with Mutated AβPP Inserted in a BALB/c Background (C.B6/J-APP(swe))
por: Balietti, Marta, et al.
Publicado: (2023)

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
por: Furio, Laetitia, et al.
Publicado: (2015)

SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilis
por: Brunet, Yannick R., et al.
Publicado: (2019)

Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer’s Patients: A Biphasic Regulation of Neurogenesis
por: Gil, Laura, et al.
Publicado: (2022)

Cdk1 and SUMO Regulate Swe1 Stability
por: Simpson-Lavy, Kobi J., et al.
Publicado: (2010)

Cohort profile: the Swedish Pancreatitis Cohort (SwePan)
por: Selin, Daniel, et al.
Publicado: (2022)

2D-SWE of the Metacarpophalangeal Joint Capsule in Horses
por: Guerri, Giulia, et al.
Publicado: (2022)

Development of the Swedish anticholinergic burden scale (Swe-ABS)
por: Rube, Tanja, et al.
Publicado: (2023)

Role of primary aging hallmarks in Alzheimer´s disease
por: Zhao, Jin, et al.
Publicado: (2023)

Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors
por: Kobayashi, Akira
Publicado: (2020)

Effect of genotype and age on cerebral [(18)F]FDG uptake varies between transgenic APP(Swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer’s disease
por: Snellman, Anniina, et al.
Publicado: (2019)

Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell
por: Yoon, Jeong-Hyun, et al.
Publicado: (2021)

Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
por: Rimal, Suman, et al.
Publicado: (2021)

Biological and disease hallmarks of Alzheimer’s disease defined by Alzheimer’s disease genes
por: Murakami, Shin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0j94b65888aulht172687ksk3t