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Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis
The study involved clinical and laboratory examination of 54 women with vasomotor menopausal disorders divided into 3 subgroups depending on the duration of symptoms (not more than 12 months, about 3 years, from 5 to 7 years). The control group included 21 patients without vasomotor disorders during...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999096/ https://www.ncbi.nlm.nih.gov/pubmed/35419113 http://dx.doi.org/10.25122/jml-2021-0106 |
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author | Pavlovska, Oksana Mykolaivna Pavlovska, Kateryna Mykolaivna Heryak, Svitlana Mykolaivna Khmil, Stefan Volodymyrovych Khmil, Mariya Stefanivna |
author_facet | Pavlovska, Oksana Mykolaivna Pavlovska, Kateryna Mykolaivna Heryak, Svitlana Mykolaivna Khmil, Stefan Volodymyrovych Khmil, Mariya Stefanivna |
author_sort | Pavlovska, Oksana Mykolaivna |
collection | PubMed |
description | The study involved clinical and laboratory examination of 54 women with vasomotor menopausal disorders divided into 3 subgroups depending on the duration of symptoms (not more than 12 months, about 3 years, from 5 to 7 years). The control group included 21 patients without vasomotor disorders during the menopausal period. Data from the general and obstetric-gynecological anamnesis and the results of objective and general clinical examinations were analyzed. To assess the state of intestinal microbiocenosis in patients, a bacteriological study of feces was used according to modern methods. In women with menopausal vasomotor disorders, chronic arterial hypertension, overweight, diabetes mellitus, chronic enterocolitis, and chronic pyelonephritis prevailed among somatic diseases. The study also revealed that these patients had a pronounced imbalance of the intensive microbiota, which was characterized by a significant decrease in the main representatives of the obligate microflora (Bifidobacterium, Lactobacillus) and an increase in the number of opportunistic strains (Klebsiella and Clostridiodes difficile). Considering modern concepts, a change in the microbial composition of the intestine may be one of the possible trigger factors for the occurrence of vasomotor menopausal disorders. Further research will clarify the influence of the microbiome on the formation of the pathological menopausal symptom complex and improve the preventive and therapeutic measures in this category of women. |
format | Online Article Text |
id | pubmed-8999096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89990962022-04-12 Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis Pavlovska, Oksana Mykolaivna Pavlovska, Kateryna Mykolaivna Heryak, Svitlana Mykolaivna Khmil, Stefan Volodymyrovych Khmil, Mariya Stefanivna J Med Life Original Article The study involved clinical and laboratory examination of 54 women with vasomotor menopausal disorders divided into 3 subgroups depending on the duration of symptoms (not more than 12 months, about 3 years, from 5 to 7 years). The control group included 21 patients without vasomotor disorders during the menopausal period. Data from the general and obstetric-gynecological anamnesis and the results of objective and general clinical examinations were analyzed. To assess the state of intestinal microbiocenosis in patients, a bacteriological study of feces was used according to modern methods. In women with menopausal vasomotor disorders, chronic arterial hypertension, overweight, diabetes mellitus, chronic enterocolitis, and chronic pyelonephritis prevailed among somatic diseases. The study also revealed that these patients had a pronounced imbalance of the intensive microbiota, which was characterized by a significant decrease in the main representatives of the obligate microflora (Bifidobacterium, Lactobacillus) and an increase in the number of opportunistic strains (Klebsiella and Clostridiodes difficile). Considering modern concepts, a change in the microbial composition of the intestine may be one of the possible trigger factors for the occurrence of vasomotor menopausal disorders. Further research will clarify the influence of the microbiome on the formation of the pathological menopausal symptom complex and improve the preventive and therapeutic measures in this category of women. Carol Davila University Press 2022-02 /pmc/articles/PMC8999096/ /pubmed/35419113 http://dx.doi.org/10.25122/jml-2021-0106 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Pavlovska, Oksana Mykolaivna Pavlovska, Kateryna Mykolaivna Heryak, Svitlana Mykolaivna Khmil, Stefan Volodymyrovych Khmil, Mariya Stefanivna Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title | Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title_full | Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title_fullStr | Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title_full_unstemmed | Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title_short | Vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
title_sort | vasomotor menopausal disorders as a possible result of dysfunction of the microbiota-intestine-brain axis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999096/ https://www.ncbi.nlm.nih.gov/pubmed/35419113 http://dx.doi.org/10.25122/jml-2021-0106 |
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