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Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas
Red blood cell distribution width (RDW), an integral parameter of the complete blood count (CBC), has been traditionally used for the classification of several types of anemia. However, over the last decade RDW has been associated with outcome in patients with several cardiovascular diseases includi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999162/ https://www.ncbi.nlm.nih.gov/pubmed/35407558 http://dx.doi.org/10.3390/jcm11071951 |
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author | Xanthopoulos, Andrew Giamouzis, Grigorios Dimos, Apostolos Skoularigki, Evangelia Starling, Randall C. Skoularigis, John Triposkiadis, Filippos |
author_facet | Xanthopoulos, Andrew Giamouzis, Grigorios Dimos, Apostolos Skoularigki, Evangelia Starling, Randall C. Skoularigis, John Triposkiadis, Filippos |
author_sort | Xanthopoulos, Andrew |
collection | PubMed |
description | Red blood cell distribution width (RDW), an integral parameter of the complete blood count (CBC), has been traditionally used for the classification of several types of anemia. However, over the last decade RDW has been associated with outcome in patients with several cardiovascular diseases including heart failure. The role of RDW in acute, chronic and advanced heart failure is the focus of the present work. Several pathophysiological mechanisms of RDW’s increase in heart failure have been proposed (i.e., inflammation, oxidative stress, adrenergic stimulation, undernutrition, ineffective erythropoiesis, reduced iron mobilization, etc.); however, the exact mechanism remains unknown. Although high RDW values at admission and discharge have been associated with adverse prognosis in hospitalized heart failure patients, the prognostic role of in-hospital RDW changes (ΔRDW) remains debatable. RDW has been incorporated in recent heart failure prognostic models. Utilizing RDW as a treatment target in heart failure may be a promising area of research. |
format | Online Article Text |
id | pubmed-8999162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89991622022-04-12 Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas Xanthopoulos, Andrew Giamouzis, Grigorios Dimos, Apostolos Skoularigki, Evangelia Starling, Randall C. Skoularigis, John Triposkiadis, Filippos J Clin Med Review Red blood cell distribution width (RDW), an integral parameter of the complete blood count (CBC), has been traditionally used for the classification of several types of anemia. However, over the last decade RDW has been associated with outcome in patients with several cardiovascular diseases including heart failure. The role of RDW in acute, chronic and advanced heart failure is the focus of the present work. Several pathophysiological mechanisms of RDW’s increase in heart failure have been proposed (i.e., inflammation, oxidative stress, adrenergic stimulation, undernutrition, ineffective erythropoiesis, reduced iron mobilization, etc.); however, the exact mechanism remains unknown. Although high RDW values at admission and discharge have been associated with adverse prognosis in hospitalized heart failure patients, the prognostic role of in-hospital RDW changes (ΔRDW) remains debatable. RDW has been incorporated in recent heart failure prognostic models. Utilizing RDW as a treatment target in heart failure may be a promising area of research. MDPI 2022-03-31 /pmc/articles/PMC8999162/ /pubmed/35407558 http://dx.doi.org/10.3390/jcm11071951 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xanthopoulos, Andrew Giamouzis, Grigorios Dimos, Apostolos Skoularigki, Evangelia Starling, Randall C. Skoularigis, John Triposkiadis, Filippos Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title | Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title_full | Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title_fullStr | Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title_full_unstemmed | Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title_short | Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas |
title_sort | red blood cell distribution width in heart failure: pathophysiology, prognostic role, controversies and dilemmas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999162/ https://www.ncbi.nlm.nih.gov/pubmed/35407558 http://dx.doi.org/10.3390/jcm11071951 |
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