Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients

Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB managem...

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Detalles Bibliográficos
Autores principales: Papagni, Roberta, Pellegrino, Carmen, Di Gennaro, Francesco, Patti, Giulia, Ricciardi, Aurelia, Novara, Roberta, Cotugno, Sergio, Musso, Maria, Guido, Giacomo, Ronga, Luigi, Stolfa, Stefania, Bavaro, Davide Fiore, Romanelli, Federica, Totaro, Valentina, Lattanzio, Rossana, De Iaco, Giuseppina, Palmieri, Fabrizio, Saracino, Annalisa, Gualano, Gina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999210/
https://www.ncbi.nlm.nih.gov/pubmed/35409219
http://dx.doi.org/10.3390/ijms23073860
Descripción
Sumario:Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels.

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