Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients

Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB managem...

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Autores principales: Papagni, Roberta, Pellegrino, Carmen, Di Gennaro, Francesco, Patti, Giulia, Ricciardi, Aurelia, Novara, Roberta, Cotugno, Sergio, Musso, Maria, Guido, Giacomo, Ronga, Luigi, Stolfa, Stefania, Bavaro, Davide Fiore, Romanelli, Federica, Totaro, Valentina, Lattanzio, Rossana, De Iaco, Giuseppina, Palmieri, Fabrizio, Saracino, Annalisa, Gualano, Gina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999210/
https://www.ncbi.nlm.nih.gov/pubmed/35409219
http://dx.doi.org/10.3390/ijms23073860
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author Papagni, Roberta
Pellegrino, Carmen
Di Gennaro, Francesco
Patti, Giulia
Ricciardi, Aurelia
Novara, Roberta
Cotugno, Sergio
Musso, Maria
Guido, Giacomo
Ronga, Luigi
Stolfa, Stefania
Bavaro, Davide Fiore
Romanelli, Federica
Totaro, Valentina
Lattanzio, Rossana
De Iaco, Giuseppina
Palmieri, Fabrizio
Saracino, Annalisa
Gualano, Gina
author_facet Papagni, Roberta
Pellegrino, Carmen
Di Gennaro, Francesco
Patti, Giulia
Ricciardi, Aurelia
Novara, Roberta
Cotugno, Sergio
Musso, Maria
Guido, Giacomo
Ronga, Luigi
Stolfa, Stefania
Bavaro, Davide Fiore
Romanelli, Federica
Totaro, Valentina
Lattanzio, Rossana
De Iaco, Giuseppina
Palmieri, Fabrizio
Saracino, Annalisa
Gualano, Gina
author_sort Papagni, Roberta
collection PubMed
description Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels.
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spelling pubmed-89992102022-04-12 Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients Papagni, Roberta Pellegrino, Carmen Di Gennaro, Francesco Patti, Giulia Ricciardi, Aurelia Novara, Roberta Cotugno, Sergio Musso, Maria Guido, Giacomo Ronga, Luigi Stolfa, Stefania Bavaro, Davide Fiore Romanelli, Federica Totaro, Valentina Lattanzio, Rossana De Iaco, Giuseppina Palmieri, Fabrizio Saracino, Annalisa Gualano, Gina Int J Mol Sci Review Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels. MDPI 2022-03-31 /pmc/articles/PMC8999210/ /pubmed/35409219 http://dx.doi.org/10.3390/ijms23073860 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Papagni, Roberta
Pellegrino, Carmen
Di Gennaro, Francesco
Patti, Giulia
Ricciardi, Aurelia
Novara, Roberta
Cotugno, Sergio
Musso, Maria
Guido, Giacomo
Ronga, Luigi
Stolfa, Stefania
Bavaro, Davide Fiore
Romanelli, Federica
Totaro, Valentina
Lattanzio, Rossana
De Iaco, Giuseppina
Palmieri, Fabrizio
Saracino, Annalisa
Gualano, Gina
Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title_full Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title_fullStr Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title_full_unstemmed Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title_short Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
title_sort impact of vitamin d in prophylaxis and treatment in tuberculosis patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999210/
https://www.ncbi.nlm.nih.gov/pubmed/35409219
http://dx.doi.org/10.3390/ijms23073860
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