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Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways

Previous research has identified an association between external radiation and disc degeneration, but the mechanism was poorly understood. This study explores the effects of ionizing radiation (IR) on inducing cellular senescence of annulus fibrosus (AF) in cell culture and in an in vivo mouse model...

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Detalles Bibliográficos
Autores principales:	Zhong, Jiongbiao, Chen, Joseph, Oyekan, Anthony A., Epperly, Michael W., Greenberger, Joel S., Lee, Joon Y., Sowa, Gwendolyn A., Vo, Nam V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999232/ https://www.ncbi.nlm.nih.gov/pubmed/35409374 http://dx.doi.org/10.3390/ijms23074014

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