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Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020

Background: The purpose of this study was to describe temporal trends in the use of antiretroviral therapy (ART) among people living with HIV (PLWHIV) from the cohort of the Spanish HIV/AIDS research network (CoRIS), 2004–2020. Methods: We described the yearly evolution of the proportion of patients...

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Autores principales: Ruiz-Algueró, Marta, Hernando, Victoria, Riero, María, Blanco Ramos, José Ramón, de Zarraga Fernández, Miguel Alberto, Galindo, Pepa, Pérez-González, Alexandre, Díaz, Asunción, Suárez-García, Inés, Jarrín, Inma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999235/
https://www.ncbi.nlm.nih.gov/pubmed/35407504
http://dx.doi.org/10.3390/jcm11071896
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author Ruiz-Algueró, Marta
Hernando, Victoria
Riero, María
Blanco Ramos, José Ramón
de Zarraga Fernández, Miguel Alberto
Galindo, Pepa
Pérez-González, Alexandre
Díaz, Asunción
Suárez-García, Inés
Jarrín, Inma
author_facet Ruiz-Algueró, Marta
Hernando, Victoria
Riero, María
Blanco Ramos, José Ramón
de Zarraga Fernández, Miguel Alberto
Galindo, Pepa
Pérez-González, Alexandre
Díaz, Asunción
Suárez-García, Inés
Jarrín, Inma
author_sort Ruiz-Algueró, Marta
collection PubMed
description Background: The purpose of this study was to describe temporal trends in the use of antiretroviral therapy (ART) among people living with HIV (PLWHIV) from the cohort of the Spanish HIV/AIDS research network (CoRIS), 2004–2020. Methods: We described the yearly evolution of the proportion of patients receiving ART and the most frequently prescribed antiretroviral drugs among newly recruited treatment-naïve patients and among all patients with active follow-up. Results: Of 15,539 patients included, 14,618 (94.1%) started ART during their follow-up. Regarding initial regimens, the use of 2NRTI plus 1NNRTI (which were the most frequently prescribed until 2014) and 2NRTI plus 1bPI decreased after 2014, being gradually replaced by INI-based triple therapies. Since 2019, other regimens started to be prescribed, mainly dual therapies. TDF/FTC/EFV was the single-tablet regimen (STR) most frequently prescribed as initial ART until 2012, decreasing thereafter as TDF/FTC/RPV, TDF/FTC/EVG/COBI, and ABC/3TC/DTG became available. TAF/FTC/BIC accounted for 53.6% of initial prescriptions in 2020, followed by DTG/3TC (24%). The percentage of patients on ART increased from 45.7% in 2004 to 98.2% in 2020. Among all patients receiving ART, regimens based on 2NRTI plus 1INI increased from 0.1% in 2007 to 53.3% in 2020. During 2007–2015, most patients were receiving TDF/FTC/EFV, which was replaced after 2017 by ABC/3TC/DTG. In 2020, 13.0% of patients were receiving dual therapies. Conclusions: Robust real-world data on ART use in PLWHIV over more than 15 years show historical trends in prescriptions with an unprecedented visualization of the contemporary treatment patterns.
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spelling pubmed-89992352022-04-12 Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020 Ruiz-Algueró, Marta Hernando, Victoria Riero, María Blanco Ramos, José Ramón de Zarraga Fernández, Miguel Alberto Galindo, Pepa Pérez-González, Alexandre Díaz, Asunción Suárez-García, Inés Jarrín, Inma J Clin Med Article Background: The purpose of this study was to describe temporal trends in the use of antiretroviral therapy (ART) among people living with HIV (PLWHIV) from the cohort of the Spanish HIV/AIDS research network (CoRIS), 2004–2020. Methods: We described the yearly evolution of the proportion of patients receiving ART and the most frequently prescribed antiretroviral drugs among newly recruited treatment-naïve patients and among all patients with active follow-up. Results: Of 15,539 patients included, 14,618 (94.1%) started ART during their follow-up. Regarding initial regimens, the use of 2NRTI plus 1NNRTI (which were the most frequently prescribed until 2014) and 2NRTI plus 1bPI decreased after 2014, being gradually replaced by INI-based triple therapies. Since 2019, other regimens started to be prescribed, mainly dual therapies. TDF/FTC/EFV was the single-tablet regimen (STR) most frequently prescribed as initial ART until 2012, decreasing thereafter as TDF/FTC/RPV, TDF/FTC/EVG/COBI, and ABC/3TC/DTG became available. TAF/FTC/BIC accounted for 53.6% of initial prescriptions in 2020, followed by DTG/3TC (24%). The percentage of patients on ART increased from 45.7% in 2004 to 98.2% in 2020. Among all patients receiving ART, regimens based on 2NRTI plus 1INI increased from 0.1% in 2007 to 53.3% in 2020. During 2007–2015, most patients were receiving TDF/FTC/EFV, which was replaced after 2017 by ABC/3TC/DTG. In 2020, 13.0% of patients were receiving dual therapies. Conclusions: Robust real-world data on ART use in PLWHIV over more than 15 years show historical trends in prescriptions with an unprecedented visualization of the contemporary treatment patterns. MDPI 2022-03-29 /pmc/articles/PMC8999235/ /pubmed/35407504 http://dx.doi.org/10.3390/jcm11071896 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruiz-Algueró, Marta
Hernando, Victoria
Riero, María
Blanco Ramos, José Ramón
de Zarraga Fernández, Miguel Alberto
Galindo, Pepa
Pérez-González, Alexandre
Díaz, Asunción
Suárez-García, Inés
Jarrín, Inma
Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title_full Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title_fullStr Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title_full_unstemmed Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title_short Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020
title_sort temporal trends and geographic variability in the prescription of antiretroviral treatments in people living with hiv in spain, 2004–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999235/
https://www.ncbi.nlm.nih.gov/pubmed/35407504
http://dx.doi.org/10.3390/jcm11071896
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