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Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population

Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. T...

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Autores principales: Palmieri, Annalisa, Lauritano, Dorina, Pellati, Agnese, Scapoli, Luca, Arcuri, Claudio, Baggi, Luigi, Gatto, Roberto, Carinci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999254/
https://www.ncbi.nlm.nih.gov/pubmed/35407543
http://dx.doi.org/10.3390/jcm11071935
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author Palmieri, Annalisa
Lauritano, Dorina
Pellati, Agnese
Scapoli, Luca
Arcuri, Claudio
Baggi, Luigi
Gatto, Roberto
Carinci, Francesco
author_facet Palmieri, Annalisa
Lauritano, Dorina
Pellati, Agnese
Scapoli, Luca
Arcuri, Claudio
Baggi, Luigi
Gatto, Roberto
Carinci, Francesco
author_sort Palmieri, Annalisa
collection PubMed
description Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. These neoplasms remain asymptomatic for a long time and, when they occur, they are already at an advanced stage. If diagnosed and treated early, oral cancer induced by human papilloma virus allows for high survival, as it often has a more favorable prognosis than oral cancers not directly related to viral infection. In this study, the presence of different high-risk and low-risk HPV strains was investigated to assess the epidemiological status in a population of healthy individuals. Two types of samples, one from the tonsils and one from the base of the tongue, were collected from 2015 healthy individuals of different sex and age. A total of 1885 DNA samples belonging to 1285 patients were tested for the presence of 11 high-risk HPV types plus 4 low-risk HPV types using real-time PCR. Of the patients’ DNA samples screened for 15 HPV types, only four samples were positive, all of which were taken from male smokers. These results indicate that newly acquired oral oncogenic HPV infections in the healthy population are rare and, in many cases, controversial. Therefore, more studies are needed to ensure fewer variations in outcomes and a greater clarification of HPV infection and its prevalence in the oropharynx of the healthy population, and to guide efforts to prevent the development of this infection which, if undiagnosed, can lead to the onset of malignant tumors in the oral cavity.
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spelling pubmed-89992542022-04-12 Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population Palmieri, Annalisa Lauritano, Dorina Pellati, Agnese Scapoli, Luca Arcuri, Claudio Baggi, Luigi Gatto, Roberto Carinci, Francesco J Clin Med Article Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. These neoplasms remain asymptomatic for a long time and, when they occur, they are already at an advanced stage. If diagnosed and treated early, oral cancer induced by human papilloma virus allows for high survival, as it often has a more favorable prognosis than oral cancers not directly related to viral infection. In this study, the presence of different high-risk and low-risk HPV strains was investigated to assess the epidemiological status in a population of healthy individuals. Two types of samples, one from the tonsils and one from the base of the tongue, were collected from 2015 healthy individuals of different sex and age. A total of 1885 DNA samples belonging to 1285 patients were tested for the presence of 11 high-risk HPV types plus 4 low-risk HPV types using real-time PCR. Of the patients’ DNA samples screened for 15 HPV types, only four samples were positive, all of which were taken from male smokers. These results indicate that newly acquired oral oncogenic HPV infections in the healthy population are rare and, in many cases, controversial. Therefore, more studies are needed to ensure fewer variations in outcomes and a greater clarification of HPV infection and its prevalence in the oropharynx of the healthy population, and to guide efforts to prevent the development of this infection which, if undiagnosed, can lead to the onset of malignant tumors in the oral cavity. MDPI 2022-03-31 /pmc/articles/PMC8999254/ /pubmed/35407543 http://dx.doi.org/10.3390/jcm11071935 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palmieri, Annalisa
Lauritano, Dorina
Pellati, Agnese
Scapoli, Luca
Arcuri, Claudio
Baggi, Luigi
Gatto, Roberto
Carinci, Francesco
Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title_full Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title_fullStr Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title_full_unstemmed Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title_short Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population
title_sort prevalence of human papillomavirus in the oropharynx of healthy individuals in an italian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999254/
https://www.ncbi.nlm.nih.gov/pubmed/35407543
http://dx.doi.org/10.3390/jcm11071935
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