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Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune res...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999260/ https://www.ncbi.nlm.nih.gov/pubmed/35407608 http://dx.doi.org/10.3390/jcm11072000 |
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author | Altet, Neus Latorre, Irene Jiménez-Fuentes, María Ángeles Soriano-Arandes, Antoni Villar-Hernández, Raquel Milà, Celia Rodríguez-Fernández, Pablo Muriel-Moreno, Beatriz Comella-del-Barrio, Patricia Godoy, Pere Millet, Joan-Pau de Souza-Galvão, Maria Luiza Jiménez-Ruiz, Carlos A. Domínguez, Jose |
author_facet | Altet, Neus Latorre, Irene Jiménez-Fuentes, María Ángeles Soriano-Arandes, Antoni Villar-Hernández, Raquel Milà, Celia Rodríguez-Fernández, Pablo Muriel-Moreno, Beatriz Comella-del-Barrio, Patricia Godoy, Pere Millet, Joan-Pau de Souza-Galvão, Maria Luiza Jiménez-Ruiz, Carlos A. Domínguez, Jose |
author_sort | Altet, Neus |
collection | PubMed |
description | Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. |
format | Online Article Text |
id | pubmed-8999260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89992602022-04-12 Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children Altet, Neus Latorre, Irene Jiménez-Fuentes, María Ángeles Soriano-Arandes, Antoni Villar-Hernández, Raquel Milà, Celia Rodríguez-Fernández, Pablo Muriel-Moreno, Beatriz Comella-del-Barrio, Patricia Godoy, Pere Millet, Joan-Pau de Souza-Galvão, Maria Luiza Jiménez-Ruiz, Carlos A. Domínguez, Jose J Clin Med Article Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. MDPI 2022-04-02 /pmc/articles/PMC8999260/ /pubmed/35407608 http://dx.doi.org/10.3390/jcm11072000 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Altet, Neus Latorre, Irene Jiménez-Fuentes, María Ángeles Soriano-Arandes, Antoni Villar-Hernández, Raquel Milà, Celia Rodríguez-Fernández, Pablo Muriel-Moreno, Beatriz Comella-del-Barrio, Patricia Godoy, Pere Millet, Joan-Pau de Souza-Galvão, Maria Luiza Jiménez-Ruiz, Carlos A. Domínguez, Jose Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title_full | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title_fullStr | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title_full_unstemmed | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title_short | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
title_sort | tobacco smoking and second-hand smoke exposure impact on tuberculosis in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999260/ https://www.ncbi.nlm.nih.gov/pubmed/35407608 http://dx.doi.org/10.3390/jcm11072000 |
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