Cargando…

Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children

Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune res...

Descripción completa

Detalles Bibliográficos
Autores principales: Altet, Neus, Latorre, Irene, Jiménez-Fuentes, María Ángeles, Soriano-Arandes, Antoni, Villar-Hernández, Raquel, Milà, Celia, Rodríguez-Fernández, Pablo, Muriel-Moreno, Beatriz, Comella-del-Barrio, Patricia, Godoy, Pere, Millet, Joan-Pau, de Souza-Galvão, Maria Luiza, Jiménez-Ruiz, Carlos A., Domínguez, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999260/
https://www.ncbi.nlm.nih.gov/pubmed/35407608
http://dx.doi.org/10.3390/jcm11072000
_version_ 1784685145985384448
author Altet, Neus
Latorre, Irene
Jiménez-Fuentes, María Ángeles
Soriano-Arandes, Antoni
Villar-Hernández, Raquel
Milà, Celia
Rodríguez-Fernández, Pablo
Muriel-Moreno, Beatriz
Comella-del-Barrio, Patricia
Godoy, Pere
Millet, Joan-Pau
de Souza-Galvão, Maria Luiza
Jiménez-Ruiz, Carlos A.
Domínguez, Jose
author_facet Altet, Neus
Latorre, Irene
Jiménez-Fuentes, María Ángeles
Soriano-Arandes, Antoni
Villar-Hernández, Raquel
Milà, Celia
Rodríguez-Fernández, Pablo
Muriel-Moreno, Beatriz
Comella-del-Barrio, Patricia
Godoy, Pere
Millet, Joan-Pau
de Souza-Galvão, Maria Luiza
Jiménez-Ruiz, Carlos A.
Domínguez, Jose
author_sort Altet, Neus
collection PubMed
description Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response.
format Online
Article
Text
id pubmed-8999260
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89992602022-04-12 Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children Altet, Neus Latorre, Irene Jiménez-Fuentes, María Ángeles Soriano-Arandes, Antoni Villar-Hernández, Raquel Milà, Celia Rodríguez-Fernández, Pablo Muriel-Moreno, Beatriz Comella-del-Barrio, Patricia Godoy, Pere Millet, Joan-Pau de Souza-Galvão, Maria Luiza Jiménez-Ruiz, Carlos A. Domínguez, Jose J Clin Med Article Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. MDPI 2022-04-02 /pmc/articles/PMC8999260/ /pubmed/35407608 http://dx.doi.org/10.3390/jcm11072000 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Altet, Neus
Latorre, Irene
Jiménez-Fuentes, María Ángeles
Soriano-Arandes, Antoni
Villar-Hernández, Raquel
Milà, Celia
Rodríguez-Fernández, Pablo
Muriel-Moreno, Beatriz
Comella-del-Barrio, Patricia
Godoy, Pere
Millet, Joan-Pau
de Souza-Galvão, Maria Luiza
Jiménez-Ruiz, Carlos A.
Domínguez, Jose
Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title_full Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title_fullStr Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title_full_unstemmed Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title_short Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
title_sort tobacco smoking and second-hand smoke exposure impact on tuberculosis in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999260/
https://www.ncbi.nlm.nih.gov/pubmed/35407608
http://dx.doi.org/10.3390/jcm11072000
work_keys_str_mv AT altetneus tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT latorreirene tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT jimenezfuentesmariaangeles tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT sorianoarandesantoni tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT villarhernandezraquel tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT milacelia tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT rodriguezfernandezpablo tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT murielmorenobeatriz tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT comelladelbarriopatricia tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT godoypere tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT milletjoanpau tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT desouzagalvaomarialuiza tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT jimenezruizcarlosa tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT dominguezjose tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren
AT tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren