Cargando…

Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles

Background: Tourette syndrome (TS) can be accompanied by neurocognitive impairment. Only a few studies have focused on executive function assessment in TS using design fluency, providing preliminary results. This study aimed to characterize the detailed design fluency profile of children with TS com...

Descripción completa

Detalles Bibliográficos
Autores principales: Tessier, Mélina, Desmarais, Annie, Leclerc, Julie B., Lavoie, Marc E., O’Connor, Kieron P., Gauthier, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999369/
https://www.ncbi.nlm.nih.gov/pubmed/35407554
http://dx.doi.org/10.3390/jcm11071946
_version_ 1784685170069078016
author Tessier, Mélina
Desmarais, Annie
Leclerc, Julie B.
Lavoie, Marc E.
O’Connor, Kieron P.
Gauthier, Bruno
author_facet Tessier, Mélina
Desmarais, Annie
Leclerc, Julie B.
Lavoie, Marc E.
O’Connor, Kieron P.
Gauthier, Bruno
author_sort Tessier, Mélina
collection PubMed
description Background: Tourette syndrome (TS) can be accompanied by neurocognitive impairment. Only a few studies have focused on executive function assessment in TS using design fluency, providing preliminary results. This study aimed to characterize the detailed design fluency profile of children with TS compared with neurotypical children, while addressing the central concern of frequent comorbidities in studies on TS by considering tic severity and attention-deficit/hyperactivity disorder (ADHD) symptoms and diagnosis. Methods: Sixty-one children aged between 6 and 15 years participated and were divided into a TS group (n = 28 (with ADHD n = 15)) and a control group (n = 33). Our objective was addressed by examining a wide range of measures of the Five-Point-Test, presumably sensitive to frontostriatal dysfunction. The total number of designs, repetitions, repetition ratio, unique designs, and numerical, spatial, and total strategies were examined for the total duration of the test (global measures) and at five equal time intervals (process measures). Results: The TS group produced significantly fewer numerical strategies. Groups did not differ in other global or process measures. ADHD did not affect performance. Conclusions: Children with TS do not inherently show general executive dysfunction but may present with subtle neurocognitive characteristics here revealed by comprehensive design fluency profiles.
format Online
Article
Text
id pubmed-8999369
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89993692022-04-12 Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles Tessier, Mélina Desmarais, Annie Leclerc, Julie B. Lavoie, Marc E. O’Connor, Kieron P. Gauthier, Bruno J Clin Med Article Background: Tourette syndrome (TS) can be accompanied by neurocognitive impairment. Only a few studies have focused on executive function assessment in TS using design fluency, providing preliminary results. This study aimed to characterize the detailed design fluency profile of children with TS compared with neurotypical children, while addressing the central concern of frequent comorbidities in studies on TS by considering tic severity and attention-deficit/hyperactivity disorder (ADHD) symptoms and diagnosis. Methods: Sixty-one children aged between 6 and 15 years participated and were divided into a TS group (n = 28 (with ADHD n = 15)) and a control group (n = 33). Our objective was addressed by examining a wide range of measures of the Five-Point-Test, presumably sensitive to frontostriatal dysfunction. The total number of designs, repetitions, repetition ratio, unique designs, and numerical, spatial, and total strategies were examined for the total duration of the test (global measures) and at five equal time intervals (process measures). Results: The TS group produced significantly fewer numerical strategies. Groups did not differ in other global or process measures. ADHD did not affect performance. Conclusions: Children with TS do not inherently show general executive dysfunction but may present with subtle neurocognitive characteristics here revealed by comprehensive design fluency profiles. MDPI 2022-03-31 /pmc/articles/PMC8999369/ /pubmed/35407554 http://dx.doi.org/10.3390/jcm11071946 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tessier, Mélina
Desmarais, Annie
Leclerc, Julie B.
Lavoie, Marc E.
O’Connor, Kieron P.
Gauthier, Bruno
Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title_full Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title_fullStr Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title_full_unstemmed Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title_short Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
title_sort capturing subtle neurocognitive differences in children with and without tourette syndrome through a fine-grained analysis of design fluency profiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999369/
https://www.ncbi.nlm.nih.gov/pubmed/35407554
http://dx.doi.org/10.3390/jcm11071946
work_keys_str_mv AT tessiermelina capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles
AT desmaraisannie capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles
AT leclercjulieb capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles
AT lavoiemarce capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles
AT oconnorkieronp capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles
AT gauthierbruno capturingsubtleneurocognitivedifferencesinchildrenwithandwithouttourettesyndromethroughafinegrainedanalysisofdesignfluencyprofiles