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Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Mothers’ antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother–fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse conseque...

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Autores principales: Beleza, Jorge, Stevanović-Silva, Jelena, Coxito, Pedro, Rocha, Hugo, Santos, Paulo, Ascensão, António, Ramon Torrella, Joan, Magalhães, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999565/
https://www.ncbi.nlm.nih.gov/pubmed/35409278
http://dx.doi.org/10.3390/ijms23073916
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author Beleza, Jorge
Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
author_facet Beleza, Jorge
Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
author_sort Beleza, Jorge
collection PubMed
description Mothers’ antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother–fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring’s maximal workload performance (MWP) and in some skeletal muscle (the soleus—SOL and the tibialis anterior—TA) biomarkers associated with mitochondrial biogenesis and oxidative fitness. Infant male Sprague-Dawley rats were divided into experimental groups according to mothers’ dietary and/or exercise conditions: offspring of sedentary control diet-fed or HFHS-fed mothers (C–S or HFHS–S, respectively) and of exercised HFHS-fed mothers (HFHS–E). Although maternal HFHS did not significantly alter MWP, offspring from GE dams exhibited increased MWP. Lower SOL AMPk levels in HFHS–S were reverted by GE. SOL PGC-1α, OXPHOS C-I and C-IV subunits remained unaltered by maternal diet, although increased in HFHS–E offspring. Additionally, GE prevented maternal diet-related SOL miR-378a overexpression, while upregulated miR-34a expression. Decreased TA C-IV subunit expression in HFHS–S was reverted in HFHS–E, concomitantly with the downregulation of miR-338. In conclusion, GE in HFHS-fed dams increases the offspring’s MWP, which seems to be associated with the intrauterine modulation of SM mitochondrial density and functional markers.
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spelling pubmed-89995652022-04-12 Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life Beleza, Jorge Stevanović-Silva, Jelena Coxito, Pedro Rocha, Hugo Santos, Paulo Ascensão, António Ramon Torrella, Joan Magalhães, José Int J Mol Sci Article Mothers’ antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother–fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring’s maximal workload performance (MWP) and in some skeletal muscle (the soleus—SOL and the tibialis anterior—TA) biomarkers associated with mitochondrial biogenesis and oxidative fitness. Infant male Sprague-Dawley rats were divided into experimental groups according to mothers’ dietary and/or exercise conditions: offspring of sedentary control diet-fed or HFHS-fed mothers (C–S or HFHS–S, respectively) and of exercised HFHS-fed mothers (HFHS–E). Although maternal HFHS did not significantly alter MWP, offspring from GE dams exhibited increased MWP. Lower SOL AMPk levels in HFHS–S were reverted by GE. SOL PGC-1α, OXPHOS C-I and C-IV subunits remained unaltered by maternal diet, although increased in HFHS–E offspring. Additionally, GE prevented maternal diet-related SOL miR-378a overexpression, while upregulated miR-34a expression. Decreased TA C-IV subunit expression in HFHS–S was reverted in HFHS–E, concomitantly with the downregulation of miR-338. In conclusion, GE in HFHS-fed dams increases the offspring’s MWP, which seems to be associated with the intrauterine modulation of SM mitochondrial density and functional markers. MDPI 2022-04-01 /pmc/articles/PMC8999565/ /pubmed/35409278 http://dx.doi.org/10.3390/ijms23073916 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beleza, Jorge
Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_full Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_fullStr Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_full_unstemmed Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_short Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_sort gestational exercise increases male offspring’s maximal workload capacity early in life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999565/
https://www.ncbi.nlm.nih.gov/pubmed/35409278
http://dx.doi.org/10.3390/ijms23073916
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