Cargando…

The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients

Colorectal cancer (CRC) is one of the most frequently diagnosed neoplasms. Despite the advances in diagnostic tools and treatments, the number of CRC cases is increasing. Therefore, it is vital to search for new parameters that could be useful in its diagnosis. Thus, we wanted to assess the usefulne...

Descripción completa

Detalles Bibliográficos
Autores principales: Zajkowska, Monika, Dulewicz, Maciej, Kulczyńska-Przybik, Agnieszka, Safiejko, Kamil, Juchimiuk, Marcin, Konopko, Marzena, Kozłowski, Leszek, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999601/
https://www.ncbi.nlm.nih.gov/pubmed/35407400
http://dx.doi.org/10.3390/jcm11071794
_version_ 1784685225908895744
author Zajkowska, Monika
Dulewicz, Maciej
Kulczyńska-Przybik, Agnieszka
Safiejko, Kamil
Juchimiuk, Marcin
Konopko, Marzena
Kozłowski, Leszek
Mroczko, Barbara
author_facet Zajkowska, Monika
Dulewicz, Maciej
Kulczyńska-Przybik, Agnieszka
Safiejko, Kamil
Juchimiuk, Marcin
Konopko, Marzena
Kozłowski, Leszek
Mroczko, Barbara
author_sort Zajkowska, Monika
collection PubMed
description Colorectal cancer (CRC) is one of the most frequently diagnosed neoplasms. Despite the advances in diagnostic tools and treatments, the number of CRC cases is increasing. Therefore, it is vital to search for new parameters that could be useful in its diagnosis. Thus, we wanted to assess the usefulness of selected CC chemokines (CCL2, CCL4, and CCL15) in CRC. The study included 115 subjects (75 CRC patients and 40 healthy volunteers). The serum concentrations of all parameters were measured using a multiplexing method (Luminex). The CRP levels were determined by immunoturbidimetry, and the classical tumor markers (CEA and CA 19-9) were measured using CMIA (chemiluminescent microparticle immunoassay). The concentrations of all parameters were higher in the CRC group when compared to the healthy controls. The diagnostic sensitivity, specificity, positive and negative predictive value, and area under the ROC curve (AUC) of all estimated CC chemokines were higher than those of CA 19-9. Interestingly, the obtained results also suggest CCL2’s significance in the determination of local metastases and CCL4’s significance in the determination of distant metastases. However, further studies concerning the role of selected CC chemokines in the course of colorectal cancer are necessary to confirm and to fully clarify their diagnostic utility and their clinical application as markers of CRC development.
format Online
Article
Text
id pubmed-8999601
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89996012022-04-12 The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients Zajkowska, Monika Dulewicz, Maciej Kulczyńska-Przybik, Agnieszka Safiejko, Kamil Juchimiuk, Marcin Konopko, Marzena Kozłowski, Leszek Mroczko, Barbara J Clin Med Article Colorectal cancer (CRC) is one of the most frequently diagnosed neoplasms. Despite the advances in diagnostic tools and treatments, the number of CRC cases is increasing. Therefore, it is vital to search for new parameters that could be useful in its diagnosis. Thus, we wanted to assess the usefulness of selected CC chemokines (CCL2, CCL4, and CCL15) in CRC. The study included 115 subjects (75 CRC patients and 40 healthy volunteers). The serum concentrations of all parameters were measured using a multiplexing method (Luminex). The CRP levels were determined by immunoturbidimetry, and the classical tumor markers (CEA and CA 19-9) were measured using CMIA (chemiluminescent microparticle immunoassay). The concentrations of all parameters were higher in the CRC group when compared to the healthy controls. The diagnostic sensitivity, specificity, positive and negative predictive value, and area under the ROC curve (AUC) of all estimated CC chemokines were higher than those of CA 19-9. Interestingly, the obtained results also suggest CCL2’s significance in the determination of local metastases and CCL4’s significance in the determination of distant metastases. However, further studies concerning the role of selected CC chemokines in the course of colorectal cancer are necessary to confirm and to fully clarify their diagnostic utility and their clinical application as markers of CRC development. MDPI 2022-03-24 /pmc/articles/PMC8999601/ /pubmed/35407400 http://dx.doi.org/10.3390/jcm11071794 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zajkowska, Monika
Dulewicz, Maciej
Kulczyńska-Przybik, Agnieszka
Safiejko, Kamil
Juchimiuk, Marcin
Konopko, Marzena
Kozłowski, Leszek
Mroczko, Barbara
The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title_full The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title_fullStr The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title_full_unstemmed The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title_short The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
title_sort significance of selected c-c motif chemokine ligands in colorectal cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999601/
https://www.ncbi.nlm.nih.gov/pubmed/35407400
http://dx.doi.org/10.3390/jcm11071794
work_keys_str_mv AT zajkowskamonika thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT dulewiczmaciej thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT kulczynskaprzybikagnieszka thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT safiejkokamil thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT juchimiukmarcin thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT konopkomarzena thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT kozłowskileszek thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT mroczkobarbara thesignificanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT zajkowskamonika significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT dulewiczmaciej significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT kulczynskaprzybikagnieszka significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT safiejkokamil significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT juchimiukmarcin significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT konopkomarzena significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT kozłowskileszek significanceofselectedccmotifchemokineligandsincolorectalcancerpatients
AT mroczkobarbara significanceofselectedccmotifchemokineligandsincolorectalcancerpatients