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The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bonding at cysteine residues and glycosylation in the HD on CAR-T...
Autores principales: | Hirobe, Sachiko, Imaeda, Keisuke, Tachibana, Masashi, Okada, Naoki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999629/ https://www.ncbi.nlm.nih.gov/pubmed/35409419 http://dx.doi.org/10.3390/ijms23074056 |
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