The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity

To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bonding at cysteine residues and glycosylation in the HD on CAR-T...

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Detalles Bibliográficos
Autores principales: Hirobe, Sachiko, Imaeda, Keisuke, Tachibana, Masashi, Okada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999629/
https://www.ncbi.nlm.nih.gov/pubmed/35409419
http://dx.doi.org/10.3390/ijms23074056

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