Cargando…

Sphingosine 1-Phosphate Receptor 5 (S1P(5)) Knockout Ameliorates Adenine-Induced Nephropathy

S1P and its receptors have been reported to play important roles in the development of renal fibrosis. Although S1P(5) has barely been investigated so far, there are indications that it can influence inflammatory and fibrotic processes. Here, we report the role of S1P(5) in renal inflammation and fi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eckes, Timon, Patyna, Sammy, Koch, Alexander, Oftring, Anke, Gauer, Stefan, Obermüller, Nicholas, Schwalm, Stephanie, Schaefer, Liliana, Chun, Jerold, Gröne, Hermann-Josef, Pfeilschifter, Josef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999641/ https://www.ncbi.nlm.nih.gov/pubmed/35409312 http://dx.doi.org/10.3390/ijms23073952

Ejemplares similares

Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response
por: Patyna, Sammy, et al.
Publicado: (2022)

Preanalytical Biases in the Measurement of Human Blood Sphingolipids
por: Brunkhorst, Robert, et al.
Publicado: (2018)

Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks
por: Blankenbach, Kira V., et al.
Publicado: (2016)

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants
por: Hsieh, Louise Tzung-Harn, et al.
Publicado: (2017)

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
por: Imre, Gergely, et al.
Publicado: (2021)

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1
por: Schwiebs, Anja, et al.
Publicado: (2016)

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis
por: Coldewey, Sina M., et al.
Publicado: (2016)

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
por: Lucaciu, Alexandra, et al.
Publicado: (2020)

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study
por: Schmidt, Katrin G., et al.
Publicado: (2017)

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
por: Evrard, Maximilien, et al.
Publicado: (2021)

Adenine-Induced Nephropathy Reduces Atherosclerosis in ApoE Knockout Mice
por: Scherler, Laeticia, et al.
Publicado: (2022)

Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality
por: Mücke, Victoria T., et al.
Publicado: (2020)

Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
por: Grammatikos, Georgios, et al.
Publicado: (2016)

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge
por: Stepanovska, Bisera, et al.
Publicado: (2020)

C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma
por: Wilhelm, Raphael, et al.
Publicado: (2021)

Sphingosine 1-phosphate levels in cerebrospinal fluid after subarachnoid hemorrhage
por: Männer, Anika, et al.
Publicado: (2020)

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives
por: Lucaciu, Alexandra, et al.
Publicado: (2020)

The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
por: Nasrullah, Usman, et al.
Publicado: (2023)

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt
por: Schwalm, Stephanie, et al.
Publicado: (2020)

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects
por: Chun, Jerold, et al.
Publicado: (2020)

Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate
por: Liu, Shian, et al.
Publicado: (2022)

Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts
por: Talmont, Franck, et al.
Publicado: (2022)

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
por: Hafizi, Redona, et al.
Publicado: (2022)

Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes
por: Dusaban, Stephanie S., et al.
Publicado: (2017)

Deletion of Sphingosine 1‐Phosphate receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis
por: Jorgensen, Ryan, et al.
Publicado: (2021)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage
por: Vienken, Hans, et al.
Publicado: (2017)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes
por: Doller, Anke, et al.
Publicado: (2013)

The association of an adenine insertion variant in the 5’UTR of the endothelin-1 gene with hypertension and orthostatic hypotension
por: Fan, Xiao-han, et al.
Publicado: (2012)

The complex pathology of diabetic nephropathy in humans
por: Kriz, Wilhelm, et al.
Publicado: (2023)

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5
por: Behrangi, Newshan, et al.
Publicado: (2022)

Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease
por: Gauer, Stefan, et al.
Publicado: (2016)

The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P(3) Regulates MAdCAM-1(+) Endothelial Cells in Splenic Marginal Sinus Organization
por: Girkontaite, Irute, et al.
Publicado: (2004)

Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5
por: Selkirk, Julie V., et al.
Publicado: (2022)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
por: Matula, Kasia, et al.
Publicado: (2015)

Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro
por: Jakobi, Katja, et al.
Publicado: (2020)

The Bologna agreement is not suitable for medical education: a German view
por: Pfeilschifter, Josef
Publicado: (2010)

Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels
por: Grammatikos, Georgios, et al.
Publicado: (2016)

Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice
por: Lyu, Bingqing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ccbv9ef2l1bd2fmndtlvkkvsr5